The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4

被引：19

作者：

Plant, Pamela J. ^{[1
]}

Correa, Judy ^{[1
]}

Goldenberg, Neil ^{[1
]}

Bain, James ^{[3
]}

Batt, Jane ^{[1
,2
]}

机构：

[1] Univ Toronto, Div Clin Sci, Dept Med, Toronto, ON M5S 1A8, Canada

[2] St Michaels Hosp, Dept Med, Toronto, ON M5B 1W8, Canada

[3] MacMaster Univ Hosp, Dept Surg, Hamilton, ON L8N 3Z5, Canada

来源：

BIOCHEMICAL JOURNAL | 2009年 / 419卷

关键词：

inositol phosphatase; muscle atrophy; myotubularin; myotubularin-related protein 4 (MTMR4); neural-precursor-cell-expressed developmentally down-regulated 4 (Nedd4); ubiquitin ligase; EPITHELIAL NA+ CHANNEL; C2; DOMAIN; MULTIVESICULAR-BODY; MEMBRANE-TRANSPORT; SKELETAL-MUSCLE; PHOSPHOINOSITIDES; MYOTUBULARINS; LOCALIZATION; ASSOCIATION; SPECIFICITY;

D O I：

10.1042/BJ20081866

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The inositol phosphatase, MTMR4 (myotubularin-related protein 4), was identified as a novel interactor of the ubiquitin ligase Nedd4 (neural-precursor-cell-expressed developmentally down-regulated 4). hMTMR4 (human MTMR4) and Nedd4 co-immunoprecipitated and co-localized to late endosomes, The PY (Pro-Tyr) motif of hMTMR4 binds to WW (Trp-Trp) domains of hNedd4. MTMR4 expression was decreased in atrophying Muscle, whereas Nedd4 expression was increased and hMTMR4 was ubiquitinated by hNedd4, suggesting that this novel interaction may underlie the biological process of muscle breakdown.

引用

页码：57 / 63

页数：7

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