Shahidine, a novel and highly labile oxazoline from Aegle marmelos: the parent compound of aegeline and related amides

被引：22

作者：

Faizi, Shaheen ^{[1
]}

Farooqi, Fatima ^{[2
]}

Zikr-Ur-Rehman, Sadia ^{[1
]}

Naz, Aneela ^{[1
]}

Noor, Fatima ^{[2
]}

Ansari, Farheen ^{[3
]}

Ahmad, Aqeel ^{[3
]}

Khan, Shakeel Ahmed ^{[3
]}

机构：

[1] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan

[2] Univ Karachi, Dept Chem, Karachi 75270, Pakistan

[3] Univ Karachi, Dept Microbiol, Karachi 75270, Pakistan

来源：

TETRAHEDRON | 2009年 / 65卷 / 05期

关键词：

Aegle marmelos; Oxazoline; Amides; Antibacterial activity; ZANTHOXYLUM-SYNCARPUM; ALKALOIDS; CONSTITUENTS; LEAVES; CORREA; CHEMISTRY; RUTACEAE; FRUITS;

D O I：

10.1016/j.tet.2008.11.088

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rare alkaloid, shahidine (1), having an unstable oxazoline core has been isolated as a major constituent from the fresh leaves of Aegle marmelos. It is moisture-sensitive, and found to be the parent compound of aegeline and other amides, however. it is stable in dimethyl sulfoxide. Its structure was established by spectroscopic analysis. Biogenetically, oxazolines may be considered as the precursor of hydroxy amides and oxazoles found in plants. Shahidine (1) showed activity against a few Gram-positive bacteria. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：998 / 1004

页数：7