Total Synthesis of the Neoclerodane Diterpene Salvinorin A via an Intramolecular Diels-Alder Strategy

被引：14

作者：

Wang, Yuzhou ^{[1
]}

Metz, Peter ^{[1
]}

机构：

[1] Tech Univ Dresden, Fak Chem & Lebensmittelchem, Organ Chem I, Bergstr 66, D-01069 Dresden, Germany

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 11期

关键词：

KAPPA-OPIOID RECEPTOR; SALVIA-DIVINORUM; AGONIST; PRODUCTS; REAGENT; MICE;

D O I：

10.1021/acs.orglett.8b01357

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise total synthesis of the neoclerodane diterpene salvinorin A from 3-furaldehyde is reported using two highly diastereoselective intramolecular Diels-Alder reactions (IMDA) as the key transformations.

引用

页码：3418 / 3421

页数：4

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