Bactericidal effect of silver-reinforced carbon nanotube and hydroxyapatite composites

被引：40

作者：

Afzal, Mohammad Atif Faiz ^{[1
]}

Kalmodia, Sushma ^{[1
]}

Kesarwani, Pallavi ^{[2
]}

Basu, Bikramjit ^{[3
]}

Balani, Kantesh ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Mat Sci & Engn, Biomat Proc & Characterizat Lab, Kanpur 208016, Uttar Pradesh, India

[2] Visvesvaraya Natl Inst Technol, Nagpur, Maharashtra, India

[3] Indian Inst Sci, Mat Res Ctr, Lab Biomat, Bangalore 560012, Karnataka, India

来源：

JOURNAL OF BIOMATERIALS APPLICATIONS | 2013年 / 27卷 / 08期

关键词：

Antibacterial; silver; carbon nanotubes; hydroxyapatite; nanoindentation; biocomposite; MECHANICAL-PROPERTIES; MICROSTRUCTURE; TRANSLOCATION; NANOPARTICLES; CYTOTOXICITY; PARTICLES; COATINGS;

D O I：

10.1177/0885328211431856

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Bacterial infection remains an important risk factor after orthopedic surgery. The present paper reports the synthesis of hydroxyapatite-silver (HA-Ag) and carbon nanotube-silver (CNT-Ag) composites via spark plasma sintering (SPS) route. The retention of the initial phases after SPS was confirmed by phase analysis using X-ray diffraction and Raman spectroscopy. Energy dispersive spectrum analysis showed that Ag was distributed uniformly in the CNT/HA matrix. The breakage of CNTs into spheroid particles at higher temperatures (1700 degrees C) is attributed to the Rayleigh instability criterion. Mechanical properties (hardness and elastic modulus) of the samples were evaluated using nanoindentation testing. Ag reinforcement resulted in the enhancement of hardness (by similar to 15%) and elastic modulus (similar to 5%) of HA samples, whereas Ag reinforcement in CNT, Ag addition does not have much effect on hardness (0.3 GPa) and elastic modulus (5 GPa). The antibacterial tests performed using Escherichia coli and Staphylococcus epidermidis showed significant decrease (by similar to 65-86%) in the number of adhered bacteria in HA/CNT composites reinforced with 5% Ag nanoparticles. Thus, Ag-reinforced HA/CNT can serve as potential antibacterial biocomposites.

引用

页码：967 / 978

页数：12