Silymarin for HCV infection

被引：50

作者：

Polyak, Stephen J. ^{[1
,2
,3
]}

Oberlies, Nicholas H. ^{[4
]}

Pecheur, Eve-Isabelle ^{[5
]}

Dahari, Harel ^{[6
,7
]}

Ferenci, Peter ^{[8
]}

Pawlotsky, Jean-Michel ^{[9
,10
]}

机构：

[1] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA

[2] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA

[3] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA

[4] Univ N Carolina, Dept Chem & Biochem, Greensboro, NC 27412 USA

[5] CNRS 5286, UMR INSERM 1052, Lyon, France

[6] Univ Illinois, Dept Med, Chicago, IL USA

[7] Los Alamos Natl Lab, Los Alamos, NM USA

[8] Med Univ Vienna, Vienna, Austria

[9] Univ Paris Est, Henri Mondor Hosp, Dept Virol, Natl Reference Ctr Viral Hepatitis B C & Delta, Creteil, France

[10] Hop Henri Mondor, INSERM, U955, F-94010 Creteil, France

来源：

ANTIVIRAL THERAPY | 2013年 / 18卷 / 02期

关键词：

HEPATITIS-C-VIRUS; FATTY LIVER-DISEASE; LONG-TERM TREATMENT; MILK THISTLE; PHASE-I; SILIBININ DIASTEREOMERS; SILYBUM-MARIANUM; RESCUE TREATMENT; PLASMA; CANCER;

D O I：

10.3851/IMP2402

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Silymarin, an extract of milk thistle seeds, and silymarinderived compounds have been considered hepatoprotective since the plant was first described in ancient times. Hepatoprotection is defined as several non-mutually exclusive biological activities including antiviral, antioxidant, anti-inflammatory and immunomodulatory functions. Despite clear evidence for silymarin-induced hepatoprotection in cell culture and animal models, evidence for beneficial effects in humans has been equivocal. This review will summarize the current state of knowledge on silymarin in the context of HCV infection. The information was collated from a recent workshop on silibinin in Germany.

引用

页码：141 / 147

页数：7

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