Serum Anticholinergic Activity: A Possible Peripheral Marker of the Anticholinergic Burden in the Central Nervous System in Alzheimer's Disease

被引：20

作者：

Hori, Koji ^{[1
]}

Konishi, Kimiko ^{[1
,2
]}

Tani, Masayuki ^{[3
]}

Tomioka, Hiroi ^{[3
]}

Akita, Ryo ^{[3
]}

Kitajima, Yuka ^{[4
]}

Aoki, Mari ^{[1
]}

Yokoyama, Sachiko ^{[1
]}

Azuma, Kazunari ^{[1
]}

Ikuse, Daisuke ^{[1
]}

Akashi, Norihisa ^{[3
]}

Hosoi, Misa ^{[1
]}

Jinbo, Koichi ^{[1
]}

Hachisu, Mitsugu ^{[5
]}

机构：

[1] Showa Univ, Dept Psychiat, Northern Yokohama Hosp, Kawasaki, Kanagawa 2248503, Japan

[2] Tokyo Metropolitan Tobu Med Ctr Persons Dev Multi, Tokyo 1360075, Japan

[3] Showa Univ, Karasuyama Hosp, Dept Psychiat, Tokyo 1578577, Japan

[4] Juntendo Univ, Sch Med, Dept Anesthesiol, Tokyo 1138421, Japan

[5] Showa Univ, Sch Pharmaceut Sci, Dept Clin Psychopharm, Tokyo 1578577, Japan

来源：

DISEASE MARKERS | 2014年 / 2014卷

关键词：

CHOLINE-ACETYLTRANSFERASE; COGNITIVE IMPAIRMENT; ASSOCIATION; DEMENTIA; CORTISOL; DELIRIUM; SYMPTOMS; NEURONS; PLASMA; DRUGS;

D O I：

10.1155/2014/459013

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We review the utility of serum anticholinergic activity (SAA) as a peripheral marker of anticholinergic activity (AA) in the central nervous system (CAA). We hypothesize that the compensatory mechanisms of the cholinergic system do not contribute to SAA if their system is intact and that if central cholinergic system deteriorates alone in conditions such as Alzheimer's disease or Lewy body dementia, CAA and SAA are caused by way of hyperactivity of inflammatory system and SAA is a marker of the anticholinergic burden in CNS. Taking into account the diurnal variations in the plasma levels of corticosteroids, which are thought to affect SAA, it should be measured at noon or just afterward.

引用

页数：7

共 46 条

[31] The anticholinergic risk scale and anticholinergic adverse effects in older persons [J].