Variation of the serotonin transporter gene SLC6A4 in the susceptibility to migraine with aura

被引：21

作者：

Todt, U.

Freudenberg, J.

Goebel, I.

Heinze, A.

Heinze-Kuhn, K.

Rietschel, M.

Goebel, H.

Kubisch, C.

机构：

[1] Univ Cologne, Inst Human Genet, D-50931 Cologne, Germany

[2] Univ Cologne, Inst Genet, D-50931 Cologne, Germany

[3] Univ Cologne, Ctr Mol Med Cologne, D-50931 Cologne, Germany

[4] UCSF, Dept Neurol, Labs Neurogenet, San Francisco, CA USA

[5] Kiel Pain & Headache Ctr, Kiel, Germany

[6] Heidelberg Univ, Cent Inst Mental Hlth, D-6800 Mannheim, Germany

来源：

NEUROLOGY | 2006年 / 67卷 / 09期

关键词：

POLYMORPHISM; TESTS;

D O I：

10.1212/01.wnl.0000242883.96822.93

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To replicate a reported association between migraine with aura (MA) and a promoter polymorphism in the serotonin transporter gene (SLC6A4), we performed a case-control study in a large German sample comprising 472 patients with MA and 506 controls. Neither this polymorphism nor a systematic analysis with single nucleotide polymorphisms capturing the main haplotype diversity of the SLC6A4 locus provided evidence for a contribution of SLC6A4 to the predisposition of complex inherited MA.

引用

页码：1707 / 1709

页数：3

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