Synthesis of 8-[18F]fluoroguanine derivatives:: In vivo probes for imaging gene expression with positron emission tomography

被引：56
|
作者：
Namavari, M
Barrio, JR
Toyokuni, T
Gambhir, SS
Cherry, SR
Herschman, HR
Phelps, ME
Satyamurthy, N [1 ]
机构：
[1] Univ Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Div Nucl Med, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, DOE, Lab Struct Biol & Mol Med, Los Angeles, CA 90024 USA
[3] Univ Calif Los Angeles, Sch Med, Inst Mol Biol, Los Angeles, CA 90024 USA
[4] Univ Calif Los Angeles, Sch Med, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90024 USA
来源：
NUCLEAR MEDICINE AND BIOLOGY | 2000年 / 27卷 / 02期
关键词：
8-[F-18]fluoroganciclovir; 8-[F-18]fluuropenciclovir; 8-[F-18]fluoroacyclovir; PET; gene expression;
D O I：
10.1016/S0969-8051(99)00095-5
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
A new method for the preparation of 8-[F-18]fluoroguanine derivatives based on a direct radiofluorination reaction has been developed. The radiofluorination of ganciclovir (1a) with [F-18]F-2 was carried out in absolute ethanol in the presence of tetraethylammonium hydroxide at room temperature to give 8-[F-18]fluoroganciclovir (3a) in an approximately 1% radiochemical yield. Similarly, 8-[F-18]fluoropenciclovir (3b), 8-[F-18]fluoroacyclovir (3c), and 8-[F-18]fluoroguanosine (3d) were synthesized from penciclovir (1b), acyclovir (1c), and guanosine (1d), respectively, using [F-18]F-2. The structural analyses of the final products (3a, 3b, 3c, and 3d) were carried out after F-18 decay by H-1, C-13, and F-18 nuclear magnetic resonance and high resolution mass spectroscopy. NUCL MED BIOL 27;2:157-162, 2000. (C) 2000 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：157 / 162
页数：6
相关论文
共 50 条
  • [41] Synthesis and evaluation of 18F -labeled CJ-042794 for imaging prostanoid EP4 receptor expression in cancer with positron emission tomography
    Zhang, Zhengxing
    Lau, Joseph
    Kuo, Hsiou-Ting
    Zhang, Chengcheng
    Colpo, Nadine
    Benard, Francois
    Lin, Kuo-Shyan
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (10) : 2094 - 2098
  • [42] Imaging Pancreas in Healthy and Diabetic Rodent Model Using [18F]Fallypride Positron Emission Tomography/Computed Tomography
    Garcia, Adriana
    Venugopal, Archana
    Pan, Min-Liang
    Mukherjee, Jogeshwar
    DIABETES TECHNOLOGY & THERAPEUTICS, 2014, 16 (10) : 640 - 643
  • [43] Elevated [18F]fluorodopamine turnover in brain of patients with schizophrenia:: An [18F]fluorodopa/positron emission tomography study
    Kumakura, Yoshitaka
    Cumming, Paul
    Vernaleken, Ingo
    Buchholz, Hans-Georg
    Siessmeier, Thomas
    Heinz, Andreas
    Kienast, Thorsten
    Bartenstein, Peter
    Gruender, Gerhard
    JOURNAL OF NEUROSCIENCE, 2007, 27 (30) : 8080 - 8087
  • [44] Preparation and stability of ethanol-free solution of [18F]florbetapir ([18F]AV-45) for positron emission tomography amyloid imaging
    Hayashi, Kazutaka
    Tachibana, Akiko
    Tazawa, Shusaku
    Mizukawa, Yosuke
    Osaki, Katsuhiko
    Morimoto, Yoko
    Zochi, Riyo
    Kurahashi, Masahiro
    Aki, Hatsumi
    Takahashi, Kazuhiro
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2013, 56 (05) : 295 - 300
  • [45] Automated synthesis of 11β-methoxy-4,16α-[16α-18F]difluoroestradiol (4F-M[18F]FES) for estrogen receptor imaging by positron emission tomography
    Ahmed, Naseem
    Langlois, Rejean
    Rodrigue, Serge
    Benard, Francois
    van Lier, Johan E.
    NUCLEAR MEDICINE AND BIOLOGY, 2007, 34 (04) : 459 - 464
  • [46] [18F]FDOPA positron emission tomography in manganese-exposed workers
    Criswell, Susan R.
    Nielsen, Susan Searles
    Warden, Mark
    Perlmutter, Joel S.
    Moerlein, Stephen M.
    Flores, Hubert P.
    Huang, John
    Sheppard, Lianne
    Seixas, Noah
    Checkoway, Harvey
    Racette, Brad A.
    NEUROTOXICOLOGY, 2018, 64 : 43 - 49
  • [47] The role of [18F]fluorodeoxyglucose positron emission tomography in thymic epithelial tumors
    Kaira, Kyoichi
    Sunaga, Noriaki
    Ishizuka, Tamotsu
    Shimizu, Kimihiro
    Yamamoto, Nobuyuki
    CANCER IMAGING, 2011, 11 (01) : 195 - 201
  • [48] Practical Synthesis of [18F]Pitavastatin and Evaluation of Hepatobiliary Transport Activity in Rats by Positron Emission Tomography
    Nakaoka, Takayoshi
    Uetake, Yuta
    Kaneko, Ken-ichi
    Niwa, Takashi
    Ochiai, Hidenori
    Irie, Satsuki
    Suezaki, Yoshie
    Otsuka, Natsumi
    Hayashinaka, Emi
    Wada, Yasuhiro
    Cui, Yilong
    Maeda, Kazuya
    Kusuhara, Hiroyuki
    Sugiyama, Yuichi
    Hosoya, Takamitsu
    Watanabe, Yasuyoshi
    MOLECULAR PHARMACEUTICS, 2020, 17 (06) : 1884 - 1898
  • [49] Head-to-Head comparison of [18F]FDG, [18F]FMZ, and [18F]SynVesT-1 positron emission tomography imaging in patients with drug-resistant epilepsy
    Li, Guanglei
    Lin, Zengping
    Bao, Weiqi
    Jiang, Shize
    Wang, Jie
    Huang, Qi
    Yang, Yang
    He, Juanjuan
    Huang, Yiyun
    Guan, Yihui
    Hu, Jie
    Xie, Fang
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2025, : 2258 - 2266
  • [50] Quantification of the activity of tritium produced during the routine synthesis of 18F fluorodeoxyglucose for positron emission tomography
    Marshall, C.
    Talboys, M. A.
    Bukhari, S.
    Evans, W. D.
    JOURNAL OF RADIOLOGICAL PROTECTION, 2014, 34 (02) : 435 - 444
12345