Synthesis of 8-[18F]fluoroguanine derivatives:: In vivo probes for imaging gene expression with positron emission tomography

被引：56
|
作者：
Namavari, M
Barrio, JR
Toyokuni, T
Gambhir, SS
Cherry, SR
Herschman, HR
Phelps, ME
Satyamurthy, N [1 ]
机构：
[1] Univ Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Div Nucl Med, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, DOE, Lab Struct Biol & Mol Med, Los Angeles, CA 90024 USA
[3] Univ Calif Los Angeles, Sch Med, Inst Mol Biol, Los Angeles, CA 90024 USA
[4] Univ Calif Los Angeles, Sch Med, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90024 USA
来源：
NUCLEAR MEDICINE AND BIOLOGY | 2000年 / 27卷 / 02期
关键词：
8-[F-18]fluoroganciclovir; 8-[F-18]fluuropenciclovir; 8-[F-18]fluoroacyclovir; PET; gene expression;
D O I：
10.1016/S0969-8051(99)00095-5
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
A new method for the preparation of 8-[F-18]fluoroguanine derivatives based on a direct radiofluorination reaction has been developed. The radiofluorination of ganciclovir (1a) with [F-18]F-2 was carried out in absolute ethanol in the presence of tetraethylammonium hydroxide at room temperature to give 8-[F-18]fluoroganciclovir (3a) in an approximately 1% radiochemical yield. Similarly, 8-[F-18]fluoropenciclovir (3b), 8-[F-18]fluoroacyclovir (3c), and 8-[F-18]fluoroguanosine (3d) were synthesized from penciclovir (1b), acyclovir (1c), and guanosine (1d), respectively, using [F-18]F-2. The structural analyses of the final products (3a, 3b, 3c, and 3d) were carried out after F-18 decay by H-1, C-13, and F-18 nuclear magnetic resonance and high resolution mass spectroscopy. NUCL MED BIOL 27;2:157-162, 2000. (C) 2000 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：157 / 162
页数：6
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