Neuromyelitis optica: Passive transfer to rats by human immunoglobulin

被引：192

作者：

Kinoshita, Makoto ^{[1
]}

Nakatsuji, Yuji ^{[1
]}

Kimura, Takashi ^{[3
]}

Moriya, Masayuki ^{[1
]}

Takata, Kazushiro ^{[1
]}

Okuno, Tatsusada ^{[2
]}

Kumanogoh, Atsushi ^{[2
]}

Kajiyama, Koji ^{[3
]}

Yoshikawa, Hiroo ^{[3
]}

Sakoda, Saburo ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Neurol, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Microbial Dis Res Inst, Dept Immunopathol, Suita, Osaka 5650871, Japan

[3] Hyogo Coll Med, Div Neurol, Dept Internal Med, Nishinomiya, Hyogo 6638501, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 386卷 / 04期

关键词：

Neuromyelitis optica; Aquaporin-4; Astrocyte; Passive transfer; Complement; Multiple sclerosis; Animal model; Experimental autoimmune encephalomyelitis; SPINAL-CORD LESIONS; MULTIPLE-SCLEROSIS; ANTI-AQUAPORIN-4; ANTIBODY; DIAGNOSTIC-CRITERIA; WATER CHANNEL; AQUAPORIN-4; ENCEPHALOMYELITIS; DISTINCTION; NECROSIS; JAPANESE;

D O I：

10.1016/j.bbrc.2009.06.085

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recurrent attacks of optic neuritis and myelitis are the hallmarks of both neuromyelitis optica (NMO) and multiple sclerosis (MS). NMO immunoglobulin G (NMO-IgG), which recognizes astrocytic aquaporin-4 (AQP4) water channels, is a specific serum autoantibody that distinguishes NMO from MS. The pathogenic role of the anti-AQP4 antibody (AQP4-Ab, NMO-IgG) in NMO has been speculated based on several studies in vitro. The aim of this study was to demonstrate the pathogenicity of AQP4-Ab in vivo. We obtained IgG from patients who underwent therapeutic plasmapheresis, and developed an animal model by passive transfer of IgG to rats. The active lesions of the rats exhibited pathological characteristics strikingly similar to those of NMO, marked by astrocytic loss and perivascular deposition of immunoglobulin and complements. These findings provide the first evidence of the pathogenicity of AQP4-Ab in vivo and support the therapeutic efficacy of eliminating the antibodies by plasmapheresis. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：623 / 627

页数：5

共 23 条

[1] Ibudilast, a phosphodiesterase inhibitor, ameliorates experimental autoimmune encephalomyelitis in Dark August rats [J].

Fujimoto, T ;

Sakoda, S ;

Fujimura, H ;

Yanagihara, T .

JOURNAL OF NEUROIMMUNOLOGY, 1999, 95 (1-2) :35-42

[2] Pathogenic potential of IgG binding to water channel extracellular domain in neuromyelitis optica [J].

Hinson, S. R. ;

Pittock, S. J. ;

Lucchinetti, C. F. ;

Roemer, S. F. ;

Fryer, J. P. ;

Kryzer, T. J. ;

Lennon, V. A. .

NEUROLOGY, 2007, 69 (24) :2221-2231

[3] Aquaporin-4-binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2 [J].

Hinson, Shannon R. ;

Roemer, Shanu F. ;

Lucchinetti, Claudia F. ;

Fryer, James P. ;

Kryzer, Thomas J. ;

Chamberlain, Jayne L. ;

Howe, Charles L. ;

Pittock, Sean J. ;

Lennon, Vanda A. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (11) :2473-2481

[4] Autoantibody-mediated disorders of the central nervous system [J].

Irani, Sarosh ;

Lang, Bethan .

AUTOIMMUNITY, 2008, 41 (01) :55-65

[5] Mechanisms of disease: aquaporin-4 antibodies in neuromyelitis optica [J].

Jarius, Sven ;

Paul, Friedemann ;

Franciotta, Diego ;

Waters, Patrick ;

Zipp, Frauke ;

Hohlfeld, Reinhard ;

Vincent, Angela ;

Wildemann, Brigitte .

NATURE CLINICAL PRACTICE NEUROLOGY, 2008, 4 (04) :202-214

[6] Astrocytic necrosis is induced by anti-aquaporin-4 antibody-positive serum [J].

Kinoshita, Makoto ;

Nakatsuji, Yuji ;

Moriya, Masayuki ;

Okuno, Tatsusada ;

Kumanogoh, Atsushi ;

Nakano, Misa ;

Takahashi, Toshiyuki ;

Fujihara, Kazuo ;

Tanaka, Keiko ;

Sakoda, Saburo .

NEUROREPORT, 2009, 20 (05) :508-512

[7] Apoptosis and necrosis: Detection, discrimination and phagocytosis [J].

Krysko, Dmitri V. ;

Vanden Berghe, Tom ;

D'Herde, Katharina ;

Vandenabeele, Peter .

METHODS, 2008, 44 (03) :205-221

[8] A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis [J].

Lennon, VA ;

Wingerchuk, DM ;

Kryzer, TJ ;

Pittock, SJ ;

Lucchinetti, CF ;

Fujihara, K ;

Nakashima, I ;

Weinshenker, BG .

LANCET, 2004, 364 (9451) :2106-2112

[9] IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel [J].

Lennon, VA ;

Kryzer, TJ ;

Pittock, SJ ;

Verkman, AS ;

Hinson, SR .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (04) :473-477

[10]

LININGTON C, 1988, AM J PATHOL, V130, P443

← 1 2 3 →