The role of surgical biopsy in the diagnosis of glioma in individuals with neurofibromatosis-1

被引：44

作者：

Leonard, J. R.

Perry, A.

Rubin, J. B.

King, A. A.

Chicoine, M. R.

Gutmann, D. H.

机构：

[1] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[2] St Louis Childrens Hosp, Dept Neurosurg, St Louis, MO 63178 USA

[3] St Louis Childrens Hosp, Dept Pathol & Immunol, St Louis, MO 63178 USA

[4] St Louis Childrens Hosp, Dept Pediat, St Louis, MO 63110 USA

[5] St Louis Childrens Hosp, Div Hematol Oncol & Neurol, St Louis, MO 63110 USA

来源：

NEUROLOGY | 2006年 / 67卷 / 08期

关键词：

D O I：

10.1212/01.wnl.0000240076.31298.47

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Most gliomas in neurofibromatosis type 1 (NF1) are pilocytic astrocytomas (PAs) of the optic pathway occurring in young children. However, some individuals develop gliomas that lack the typical NF1-associated clinical features or radiographic appearance. We identified 17 atypical presentations from a review of 100 patients with NF1-associated gliomas. Biopsy showed that 9 were not classic PAs. These data highlight the value of biopsy in NF1-associated gliomas with unusual clinical or radiographic presentations.

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页码：1509 / 1512

页数：4

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