High occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema

被引：10

作者：

Hofman, Zonne L. M. ^{[1
,2
]}

van West, Nikki ^{[3
]}

Hack, C. Erik ^{[2
]}

Knulst, Andre C. ^{[2
,3
]}

Maas, Coen ^{[1
]}

Rockmann, Heike ^{[3
]}

机构：

[1] Univ Utrecht, Univ Med Ctr Utrecht, Lab Clin Chem & Haematol, Utrecht, Netherlands

[2] Univ Utrecht, Univ Med Ctr Utrecht, Lab Translat Immunol, Utrecht, Netherlands

[3] Univ Utrecht, Univ Med Ctr Utrecht, Dept Dermatol Allergol, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

来源：

CLINICAL AND TRANSLATIONAL ALLERGY | 2019年 / 9卷

关键词：

Angioedema; Idiopathic angioedema; Antihistamines; Omalizumab; URTICARIA; DIAGNOSIS;

D O I：

10.1186/s13601-019-0274-7

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Antihistamines are the most prescribed therapy in recurrent idiopathic angioedema, yet little is known about their efficacy. Herein, we report on clinical improvement with antihistamine therapy in 120 patients evaluating angioedema attack frequency. A high incidence (36%) of antihistamine refractory cases was observed. Forty percent of patients on antihistamine prophylaxis suffered from 1 or more angioedema attacks per month. Our findings stress the need for additional treatment options for recurrent idiopathic angioedema.

引用

页数：5

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