COCONUT OIL: NON-ALTERNATIVE DRUG TREATMENT AGAINST ALZHEIMER'S DISEASE

被引:15
作者
Hu Yang, Ivan [1 ]
de la Rubia Orti, Jose Enrique [2 ]
Selvi Sabater, Pablo [3 ]
Sancho Castillo, Sandra [1 ]
Julian Rochina, Mariano [4 ]
Manresa Ramon, Noemi [3 ]
Montoya-Castilla, Inmaculada [4 ]
机构
[1] Univ Catolica Valencia, Valencia, Spain
[2] Univ Europea Valencia, Valencia, Spain
[3] Hosp Univ Morales Meseguer, Valencia, Spain
[4] Univ Valencia, E-46003 Valencia, Spain
关键词
Alzheimer's disease; Triglycerides; Coconut oil; Ketone bodies; DEMENTIA; TRIGLYCERIDE; DEPOSITION; EFFICACY;
D O I
10.3305/nh.2015.32.6.9707
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Alzheimer's dementia is the most prevalent nowadays. As for treatment, there is no definitive cure drug, thus new therapies are needed. In this regard the medium chain triglycerides are a direct source of cellular energy and can be a non-pharmacological alternative to the neuronal death for lack of it, that occurs in Alzheimer patients. Objective: to evaluate the impact of coconut oil in the development of Alzheimer's dementia, in any degree of dementia. Also determine whether this improvement influences within variables such as sex and suffering or not Type II Diabetes Mellitus. Material and methods: a prospective study was conducted in patients with Alzheimer's dementia, with a control and an intervention group which was administered 40 ml/day of extra virgin coconut oil. The parameters evaluated were the mini test scores Lobo cognitive test, pre and post intervention in both groups. Results: it was observed in subjects taking the product, a statistically significant increase in test score MEC-WOLF and therefore an improvement in cognitive status, improving especially women's, those without diabetes mellitus type II, and severe patients. Conclusion: this study, although preliminary, demonstrated the positive influence of coconut oil at the cognitive level of patients with Alzheimer's, this improvement being dependent on sex, presence or absence of diabetes and degree of dementia.
引用
收藏
页码:2822 / 2827
页数:6
相关论文
共 25 条
[2]  
[Anonymous], 2013, DEM PRIOR SAL PUBL
[3]   Smoking as a risk factor for dementia and cognitive decline: a meta-analysis of prospective studies [J].
Anstey, Kaarin J. ;
von Sanden, Chwee ;
Salim, Agus ;
O'Kearney, Richard .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2007, 166 (04) :367-378
[4]  
Bezar J, 1971, J AM OIL CHEM SOC, V48, P134
[5]  
Bullain Szofia S, 2013, Continuum (Minneap Minn), V19, P457, DOI 10.1212/01.CON.0000429172.27815.3f
[6]   Ageing populations: the challenges ahead [J].
Christensen, Kaare ;
Doblhammer, Gabriele ;
Rau, Roland ;
Vaupel, James W. .
LANCET, 2009, 374 (9696) :1196-1208
[7]  
Donoso Archibaldo, 2003, Rev. chil. neuro-psiquiatr., V41, P13
[8]   Effects of caprylic triglyceride on cognitive performance and cerebral glucose metabolism in mild Alzheimer's disease: a single-case observation [J].
Farah, Brian Andrew .
FRONTIERS IN AGING NEUROSCIENCE, 2014, 6
[9]   AMYLOID DEPOSITION AS THE CENTRAL EVENT IN THE ETIOLOGY OF ALZHEIMERS-DISEASE [J].
HARDY, J ;
ALLSOP, D .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (10) :383-388
[10]   The efficacy of omega-3 fatty acids on cognitive function in aging and dementia: A systematic review [J].
Issa, AM ;
Mojica, WA ;
Morton, SC ;
Traina, S ;
Newberry, SJ ;
Hilton, LG ;
Garland, RH ;
MacLean, CH .
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2006, 21 (02) :88-96