Retention in buprenorphine treatment is associated with improved HCV care outcomes

被引:34
作者
Norton, B. L. [1 ]
Beitin, A. [1 ]
Glenn, M. [1 ]
DeLuca, J. [1 ]
Litwin, A. H. [1 ]
Cunningham, C. O. [1 ]
机构
[1] Montefiore Med Ctr, Albert Einstein Coll Med, Div Gen Internal Med, Bronx, NY 10467 USA
关键词
Buprenorphine; Cascade of care; Hepatitis C; Medication assisted treatment; Opioid use disorder; HEPATITIS-C VIRUS; INJECTION-DRUG USERS; UNITED-STATES; OBSERVED THERAPY; INFECTION; PREVALENCE; METHADONE; PEOPLE; MANAGEMENT; MORTALITY;
D O I
10.1016/j.jsat.2017.01.015
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Persons who inject drugs, most of whom are opioid dependent, comprise the majority of the HCV infected in the United States. As the national opioid epidemic unfolds,"increasing numbers of people are entering the medical system to access treatment for opioid use disorder, specifically with buprenorphine. Yet little is known about HCV care in patients accessing buprenorphine-based opioid treatment. We sought to determine the HCV prevalence, cascade of care, and the association between patient characteristics and completion of HCV cascade of care milestones for patients initiating buprenorphine treatment We reviewed electronic health records of all patients who initiated buprenorphine treatment at a primary-care clinic in the Bronx, NY between January 2009 and January 2014. Of the 390 patients who initiated buprenorphine treatment, 123 were confirmed to have chronic HCV infection. The only patient characteristic associated with achieving HCV care milestones was retention in opioid treatment. Patients retained (vs. not retained) in buprenorphine treatment were more likely to be referred for HCV specialty care (63.1% vs. 34.0%, p < 0.01), achieve an HCV-specific evaluation (40.8% vs. 21.3%, p < 0.05), be offered HCV treatment (22.4% vs. 8.5%, p < 0.05), and initiate HCV treatment (9.2% vs. 6.4%, p = 0.6). Given the current opioid epidemic in the US and the growing number of people receiving buprenorphine treatment, there is an unprecedented opportunity to access and treat persons with HCV, reducing HCV transmission, morbidity and mortality. Retention in opioid treatment may improve linkage and retention in HCV care; innovative models of care that integrate opioid drug treatment with HCV treatment are essential. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码:38 / 42
页数:5
相关论文
共 44 条
[1]   Hepatitis C virus infection in the United States [J].
Alter, MJ .
JOURNAL OF HEPATOLOGY, 1999, 31 :88-91
[2]   HIV Treatment Outcomes Among HIV-Infected, Opioid-Dependent Patients Receiving Buprenorphine/Naloxone Treatment within HIV Clinical Care Settings: Results From a Multisite Study [J].
Altice, Frederick L. ;
Bruce, R. Douglas ;
Lucas, Gregory M. ;
Lum, Paula J. ;
Korthuis, P. Todd ;
Flanigan, Timothy P. ;
Cunningham, Chinazo O. ;
Sullivan, Lynn E. ;
Vergara-Rodriguez, Pamela ;
Fiellin, David A. ;
Cajina, Adan ;
Botsko, Michael ;
Nandi, Vijay ;
Gourevitch, Marc N. ;
Finkelstein, Ruth .
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2011, 56 :S22-S32
[3]   The prevalence of hepatitis C virus infection in the United States, 1999 through 2002 [J].
Armstrong, Gregory L. ;
Wasley, Annemarie ;
Simard, Edgar P. ;
McQuillan, Geraldine M. ;
Kuhnert, Wendi L. ;
Alter, Miriam J. .
ANNALS OF INTERNAL MEDICINE, 2006, 144 (10) :705-714
[4]   Outpatient drug treatment program directors' hepatitis C-related beliefs and their relationship to the provision of HCV services [J].
Astone, JM ;
Strauss, SM ;
Hagan, H ;
Jarlais, DCD .
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE, 2004, 30 (04) :783-797
[5]   Efficacy and Safety of Peginterferon Alfa-2a/Ribavirin in Methadone Maintenance Patients: Randomized Comparison of Direct Observed Therapy and Self-Administration [J].
Bonkovsky, Herbert L. ;
Tice, Alan D. ;
Yapp, Rockford G. ;
Bodenheimer, Henry C., Jr. ;
Monto, Alexander ;
Rossi, Stephen J. ;
Sulkowski, Mark S. .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2008, 103 (11) :2757-2765
[6]   Models of Care for the Management of Hepatitis C Virus Among People Who Inject Drugs: One Size Does Not Fit All [J].
Bruggmann, Philip ;
Litwin, Alain H. .
CLINICAL INFECTIOUS DISEASES, 2013, 57 :S56-S61
[7]  
[Buprenorphine Drug Enforcement Administration (DEA)], 2013, GRUG ENF ADM OFF DIV
[8]  
Centers for Disease Control and Prevention, 2013, SURV VIR HEP 2013
[9]   Hepatitis C virus infection in USA: an estimate of true prevalence [J].
Chak, Eric ;
Talal, Andrew H. ;
Sherman, Kenneth E. ;
Schiff, Eugene R. ;
Saab, Sammy .
LIVER INTERNATIONAL, 2011, 31 (08) :1090-1101
[10]  
Cunningham C, 2008, FAM MED, V40, P500