Repeated in-field radiosurgery for locally recurrent brain metastases: Feasibility, results and survival in a heavily treated patient cohort

被引:53
作者
Balermpas, Panagiotis [1 ,2 ,3 ,4 ]
Stera, Susanne [1 ]
von der Gruen, Jens Mueller [1 ]
Loutfi-Krauss, Britta [1 ]
Forster, Marie-Therese [5 ]
Wagner, Marlies [6 ]
Keller, Christian [1 ,2 ]
Roedel, Claus [1 ,3 ,4 ]
Seifert, Volker [5 ]
Blanck, Oliver [2 ,7 ]
Wolff, Robert [2 ,5 ]
机构
[1] Goethe Univ Frankfurt, Dept Radiat Oncol, Univ Hosp, Frankfurt, Germany
[2] Saphir Radiosurg Ctr, Frankfurt, Germany
[3] German Canc Res Ctr, Heidelberg, Germany
[4] German Canc Consortium DKTK Partner Site, Frankfurt, Germany
[5] Goethe Univ Frankfurt, Univ Hosp, Dept Neurosurg, Frankfurt, Germany
[6] Goethe Univ Frankfurt, Univ Hosp, Inst Neuroradiol, Frankfurt, Germany
[7] Univ Med Ctr Schleswig Holstein, Dept Radiat Oncol, Kiel, Germany
关键词
POSTOPERATIVE STEREOTACTIC RADIOSURGERY; GAMMA-KNIFE RADIOSURGERY; SURGICAL RESECTION; RADIATION-THERAPY; CEREBRAL METASTASES; SALVAGE THERAPY; BREAST-CANCER; SINGLE-CENTER; SOLID TUMORS; RADIOTHERAPY;
D O I
10.1371/journal.pone.0198692
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Purpose Stereotactic radiosurgery (SRS) is an established primary treatment for newly diagnosed brain metastases with high local control rates. However, data about local re-irradiation in case of local failure after SRS (re-SRS) are rare. We evaluated the feasibility, efficacy and patient selection characteristics in treating locally recurrent metastases with a second course of SRS. Methods We retrospectively evaluated patients with brain metastases treated with re-SRS for local tumor progression between 2011 and 2017. Patient and treatment characteristics as well as rates of tumor control, survival and toxicity were analyzed. Results Overall, 32 locally recurrent brain metastases in 31 patients were irradiated with re-SRS. Median age at re-SRS was 64.9 years. The primary histology was breast cancer and nonsmall-cellular lung cancer (NSCLC) in respectively 10 cases (31.3%), in 5 cases malignant melanoma (15.6%). In the first SRS-course 19 metastases (59.4%) and in the re-SRScourse 29 metastases (90.6%) were treated with CyberKnife (R) and the others with Gamma Knife. Median planning target volume (PTV) for re-SRS was 2.5 cm(3) (range, 0.1-37.5 cm(3)) and median dose prescribed to the PTV was 19 Gy (range, 12-28 Gy) in 1-5 fractions to the median 69% isodose (range, 53-80%). The 1-year overall survival rate was 61.7% and the 1-year local control rate was 79.5%. The overall rate of radiological radio-necrosis was 16.1% and four patients (12.9%) experienced grade >= 3 toxicities. Conclusions A second course of SRS for locally recurrent brain metastases after prior local SRS appears to be feasible with acceptable toxicity and can be considered as salvage treatment option for selected patients with high performance status. Furthermore, this is the first study utilizing robotic radiosurgery for this indication, as an additional option for frameless fractionated treatment.
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页数:18
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