Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients

被引：53
|
作者：
De Souza, Juliana M. [1 ]
Galaverna, Renan [2 ]
De Souza, Aline A. N. [1 ]
Brocksom, Timothy J. [1 ]
Pastre, Julio C. [2 ]
De Souza, Rodrigo O. M. A. [3 ]
De Oliveira, Kleber T. [1 ]
机构：
[1] Fed Univ Sao Carlos UFSCar, Dept Chem, Rodovia Washington Luis,Km 235, BR-13565905 Sao Carlos, SP, Brazil
[2] Univ Campinas UNICAMP, Inst Chem, Cidade Univ Zeferino Vaz,POB 6154, BR-13083592 Campinas, SP, Brazil
[3] Fed Univ Rio de Janeiro UFRJ, Inst Chem, Av Athos Silveira Ramos 149,Cidade Univ, BR-22941909 Rio De Janeiro, RJ, Brazil
来源：
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS | 2018年 / 90卷
基金：
巴西圣保罗研究基金会;
关键词：
Continuous flow; natural products; APIs; synthesis; PROCESS WINDOWS; ORGANIC-SYNTHESIS; AEROBIC OXIDATION; DRUG DISCOVERY; ADIPIC ACID; SCALE-UP; MICROFLOW PHOTOCHEMISTRY; PROCESS INTENSIFICATION; SUSTAINABLE SYNTHESIS; CHEMICAL-SYNTHESIS;
D O I：
10.1590/0001-3765201820170778
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We present a comprehensive review of the advent and impact of continuous flow chemistry with regard to the synthesis of natural products and drugs, important pharmaceutical products and definitely responsible for a revolution in modem healthcare. We detail the beginnings of modern drugs and the large scale batch mode of production, both chemical and microbiological. The introduction of modern continuous flow chemistry is then presented, both as a technological tool for enabling organic chemistry, and as a fundamental research endeavor. This part details the syntheses of bioactive natural products and commercial drugs.
引用
收藏
页码：1131 / 1174
页数：44
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