Regional specialization within the intestinal immune system

被引：1244

作者：

Mowat, Allan M. ^{[1
]}

Agace, William W. ^{[2
,3
]}

机构：

[1] Univ Glasgow, Ctr Immunobiol, Inst Infect Immun & Inflammat, Glasgow G12 8TA, Lanark, Scotland

[2] Lund Univ, Dept Expt Med Sci, Immunol Sect, S-22184 Lund, Sweden

[3] Danish Tech Univ, Sect Immunol & Vaccinol, Vet Inst, DK-1870 Copenhagen, Denmark

来源：

NATURE REVIEWS IMMUNOLOGY | 2014年 / 14卷 / 10期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

INFLAMMATORY-BOWEL-DISEASE; PLASMACYTOID DENDRITIC CELLS; INNATE LYMPHOID-CELLS; REGULATORY T-CELLS; ARYL-HYDROCARBON RECEPTOR; SEGMENTED FILAMENTOUS BACTERIA; IMMUNOGLOBULIN-A GENERATION; VITAMIN-B METABOLITES; LAMINA PROPRIA; MAST-CELLS;

D O I：

10.1038/nri3738

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The intestine represents the largest compartment of the immune system. It is continually exposed to antigens and imnnunomodulatory agents from the diet and the commensal microbiota, and it is the port of entry for many clinically important pathogens. Intestinal immune processes are also increasingly implicated in controlling disease development elsewhere in the body. In this Review, we detail the anatomical and physiological distinctions that are observed in the small and large intestines, and we suggest how these may account for the diversity in the immune apparatus that is seen throughout the intestine. We describe how the distribution of innate, adaptive and innate-like immune cells varies in different segments of the intestine and discuss the environmental factors that may influence this. Finally, we consider the implications of regional immune specialization for inflammatory disease in the intestine.

引用

页码：667 / 685

页数：19

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