Streptozotocin-induced diabetes provokes changes in serotonin concentration and on 5-HT1A and 5-HT2 receptors in the rat brain

被引：58
作者：
Sandrini, M
Vitale, G
Vergoni, AV
Ottani, A
Bertolini, A
机构：
[1] Department of Biomedical Sciences, Section of Pharmacology, University of Modena, I-41100 Modena
[2] Dept. of Biomedical Sci., Sect. of Pharmacology, Univ. of Modena, I-41100 Modena MO
来源：
LIFE SCIENCES | 1997年 / 60卷 / 16期
关键词：
streptozotocin; diabetes; serotonin; 5-HT1A receptor; 5-HT2; receptor; MELLITUS; STRESS;
D O I：
10.1016/S0024-3205(97)00084-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Since reduced levels of brain serotonin are known to cause behavioural abnormalities, to which diabetics are also prone, we investigated the effect, in rats, of chronic diabetes on brain serotonin concentration and on the numbers of 5-HT1A and 5-HT2 receptors in cerebral cortex and brainstem. Our data show that streptozotocin induces a longlasting hyperglicemia that is associated with a decrease in cerebral concentration of serotonin and with an accompanying increase in the maximum number of 5-HT1A and 5-HT2 receptors in the brain areas studied. Our results may suggest that changes in serotonergic transmission in the CNS play a role in diabetes-related behavioural abnormalities.
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页码：1393 / 1397
页数：5
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