Abyssomicin C -: A polycyclic antibiotic from a marine Verrucosispora strain as an inhibitor of the p-aminobenzoic acid/tetrahydrofolate biosynthesis pathway

被引：240
作者：
Bister, B
Bischoff, D
Ströbele, M
Riedlinger, J
Reicke, A
Wolter, F
Bull, AT
Zähner, H
Fiedler, HP
Süssmuth, RD
机构：
[1] Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany
[2] Univ Tubingen, Inst Anorgan Chem, D-72076 Tubingen, Germany
[3] Univ Tubingen, Inst Mikrobiol, D-72076 Tubingen, Germany
[4] Univ Kent, Res Sch Biosci, Canterbury CT2 7NJ, Kent, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 19期
关键词：
antibiotics; metabolism; Michael addition; natural products;
D O I：
10.1002/anie.200353160
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Plumbing the depths: Abyssomicin C (structure shown) from ocean floor sediment is a novel antibiotic that inhibits the biosynthesis steps between chorismate and p-aminobenzoic acid. Its activity may be explained by the irreversible trapping of the targeted enzymes by a Michael addition. Blocking the biosynthesis of p-aminobenzoic acid may be one approach to developing new antibiotics.
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页码：2574 / 2576
页数：3
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