Abyssomicin C -: A polycyclic antibiotic from a marine Verrucosispora strain as an inhibitor of the p-aminobenzoic acid/tetrahydrofolate biosynthesis pathway

被引：247

作者：

Bister, B

Bischoff, D

Ströbele, M

Riedlinger, J

Reicke, A

Wolter, F

Bull, AT

Zähner, H

Fiedler, HP

Süssmuth, RD

机构：

[1] Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany

[2] Univ Tubingen, Inst Anorgan Chem, D-72076 Tubingen, Germany

[3] Univ Tubingen, Inst Mikrobiol, D-72076 Tubingen, Germany

[4] Univ Kent, Res Sch Biosci, Canterbury CT2 7NJ, Kent, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 19期

关键词：

antibiotics; metabolism; Michael addition; natural products;

D O I：

10.1002/anie.200353160

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Plumbing the depths: Abyssomicin C (structure shown) from ocean floor sediment is a novel antibiotic that inhibits the biosynthesis steps between chorismate and p-aminobenzoic acid. Its activity may be explained by the irreversible trapping of the targeted enzymes by a Michael addition. Blocking the biosynthesis of p-aminobenzoic acid may be one approach to developing new antibiotics.

引用

页码：2574 / 2576

页数：3

共 16 条

[1]

*AM CHEM SOC, SCIF SCHOL VERS 2002

[2]

[Anonymous], 1993, NAT PROD LETT

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