Catalytic Direct β-Arylation of Simple Ketones with Aryl Iodides

被引：99
作者：
Huang, Zhongxing [1 ]
Dong, Guangbin [1 ]
机构：
[1] Univ Texas Austin, Dept Chem, Austin, TX 78712 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 47期
关键词：
C-H BONDS; ASYMMETRIC CONJUGATE ADDITION; AEROBIC DEHYDROGENATION; ARYLBORONIC ACIDS; ALPHA-ARYLATION; CARBONYL-COMPOUNDS; CYCLIC ENONES; BORONIC ACIDS; PALLADIUM; ALDEHYDES;
D O I：
10.1021/ja410389a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein we report a direct beta-arylation of simple ketones with widely available aryl iodides, combining palladium-catalyzed ketone oxidation, aryl-halide activation, and conjugate addition through a single catalytic cycle. Simple cyclic ketones with different ring-sizes, as well as acyclic ketones, can be directly arylated at the beta-position with complete site-selectivity and excellent functional group tolerance.
引用
收藏
页码：17747 / 17750
页数：4
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