Catalytic Direct β-Arylation of Simple Ketones with Aryl Iodides

被引：100

作者：

Huang, Zhongxing ^{[1
]}

Dong, Guangbin ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Chem, Austin, TX 78712 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 47期

关键词：

C-H BONDS; ASYMMETRIC CONJUGATE ADDITION; AEROBIC DEHYDROGENATION; ARYLBORONIC ACIDS; ALPHA-ARYLATION; CARBONYL-COMPOUNDS; CYCLIC ENONES; BORONIC ACIDS; PALLADIUM; ALDEHYDES;

D O I：

10.1021/ja410389a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein we report a direct beta-arylation of simple ketones with widely available aryl iodides, combining palladium-catalyzed ketone oxidation, aryl-halide activation, and conjugate addition through a single catalytic cycle. Simple cyclic ketones with different ring-sizes, as well as acyclic ketones, can be directly arylated at the beta-position with complete site-selectivity and excellent functional group tolerance.

引用

收藏

页码：17747 / 17750

页数：4

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