New Cytotoxic Alkylated Anthraquinone Analogues from a Soil Actinomycete Streptomyces sp WS-13394

被引：7

作者：

Wu, Zhao-Yuan ^{[1
]}

Fang, Wei ^{[1
]}

Shi, Li-Qiao ^{[1
]}

Wan, Zhong-Yi ^{[1
]}

Min, Yong ^{[1
]}

Wang, Kai-Mei ^{[1
]}

机构：

[1] Hubei Acad Agr Sci, Hubei Biopesticide Engn Res Ctr, Wuhan 430064, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2014年 / 62卷 / 01期

关键词：

alkylated anthraquinone; Streptomyces sp WS-13394; actinomycete; cytotoxic;

D O I：

10.1248/cpb.c13-00693

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new alkylated anthraquinone analogues (1-4) were isolated from a soil actimomycete Streptomyces sp. WS-13394. The structures of compounds 1-4 were elucidated to be 1,4,6-trihydroxy-8-alkylanthraquinones by means of spectroscopic methods, including UV, one dimensional (1D), 2D-NMR and MS spectrometry. All compounds showed activities against BGC-823 and MCF-7 with IC50 from 0.99 to 3.54 mu g/mL, while 2 exhibited cytotoxicity against HepG2, A875, BGC-823 and MCF-7 with IC50 2.29, 4.90, 0.99, and 1.66 mu g/mL, respectively.

引用

页码：118 / 121

页数：4

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