Three novel triterpenoid saponins from Lysimachia capillipes and their cytotoxic activities

被引:35
|
作者
Tian, JK [1 ]
Xu, LZ
Zou, ZM
Yang, SL
机构
[1] Zhejiang Univ, Dept Chinese Med Sci & Engn, Hangzhou 310028, Peoples R China
[2] Chinese Acad Med Sci, Inst Med Plants Dev, Beijing 100094, Peoples R China
[3] Peking Union Med Coll, Beijing 100094, Peoples R China
关键词
Lysimachia capillipes; capilliposide A; capilliposide B; capilliposide C; triterpene; saponin;
D O I
10.1248/cpb.54.567
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Three new saponins, capilliposide A (1), capilliposide B (2) and capilliposide C (3) were isolated from an ethanol extract of Lysimachia capillipes. Their structures were determined by 1D and 2D NMR (H-1-H-1 COSY, HMBC, HMQC, DEPT and TOCSY) techniques, MS, and hydrolysis. Capilliposide B showed significant cytotoxicity against human A-2780 cells.
引用
收藏
页码:567 / 569
页数:3
相关论文
共 50 条
  • [31] Cytotoxic triterpenoid saponins from the roots of Platycodon grandiflorum
    Zhang, Lin
    Liu, Zhen-Huan
    Tian, Jing-Kui
    MOLECULES, 2007, 12 (04): : 832 - 841
  • [32] Triterpenoid Saponins from Ardisia pusilla and their Cytotoxic Activity
    Tian, Ye
    Tang, Hai-Feng
    Qiu, Feng
    Wang, Xiao-Juan
    Chen, Xiao-Li
    Wen, Ai-Dong
    PLANTA MEDICA, 2009, 75 (01) : 70 - 75
  • [33] Cytotoxic Triterpenoid Saponins from the Rhizomes of Anemone taipaiensis
    Wang, Xiao-Yang
    Chen, Xiao-Li
    Tang, Hai-Feng
    Gao, Hui
    Tian, Xiang-Rong
    Zhang, Ping-Hu
    PLANTA MEDICA, 2011, 77 (13) : 1550 - 1554
  • [34] Cytotoxic oxygenated triterpenoid saponins from Symplocos chinensis
    Fu, Guangmiao
    Liu, Yue
    Yu, Shishan
    Huang, Xiangzhong
    Hu, Youcai
    Chen, Xiaoguang
    Zhang, Furong
    JOURNAL OF NATURAL PRODUCTS, 2006, 69 (12): : 1680 - 1686
  • [35] Cytotoxic oleanane triterpenoid saponins from Albizia julibrissin
    Han, Qinghua
    Qian, Yi
    Wang, Xuda
    Zhang, Qingying
    Cui, Jingrong
    Tu, Pengfei
    Liang, Hong
    FITOTERAPIA, 2017, 121 : 183 - 193
  • [36] Cytotoxic triterpenoid saponins from the roots of Cephalaria gigantea
    Tabatadze, Nino
    Elias, Riad
    Faure, Robert
    Geryens, Pascal
    De Pauw-Gillet, Marie Claire
    Kemertelidze, Ether
    Chea, Aun
    Ollivier, Evelyne
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2007, 55 (01) : 102 - 105
  • [37] Cytotoxic Triterpenoid Saponins from the Stems of Gordonia longicarpa
    Tang, Jia
    Yu, Lei
    Fu, Huizheng
    Li, Chuangjun
    Yang, Jingzhi
    Zhou, Wanqi
    Chen, Xiaoguang
    Zhang, Dongming
    PLANTA MEDICA, 2013, 79 (05) : 353 - 360
  • [38] Cytotoxic Effects of Oleanane-type Saponins from Lysimachia laxa
    Huyen, Le Thi
    Bao, Dang Gia
    Son, Nguyen Thi
    Anh, Nguyen Thi Van
    Tai, Bui Huu
    Huong, Phan Thi Thanh
    Kiem, Phan Van
    Thuy, Nguyen Thi Kim
    Hanh, Nguyen Thi
    Park, Seonju
    Nhiem, Nguyen Xuan
    CHEMISTRY & BIODIVERSITY, 2024, 21 (12)
  • [39] Triterpenoid Saponins with Potential Cytotoxic Activities from the Root Bark of Ilex rotunda Thunb.
    Liu, Wei-Jie
    Peng, Yu-Yuan
    Chen, Hao
    Liu, Xian-Fang
    Liang, Jing-Yu
    Sun, Jian-Bo
    CHEMISTRY & BIODIVERSITY, 2017, 14 (02)
  • [40] Triterpenoid Saponins and Flavonoid Glycosides from the Flower of Camellia flavida and Their Cytotoxic and α-Glycosidase Inhibitory Activities
    Ma, Siyuan
    Wu, Yuxin
    Min, Hanfeng
    Ge, Li
    Yang, Kedi
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (20)