Diversification of Peptidomimetics and Oligopeptides through Microwave-Assisted Rhodium(III)-Catalyzed Intramolecular Annulation

被引：22

作者：

Song, Liangliang ^{[1
]}

Tian, Guilong ^{[1
]}

Blanpain, Anna ^{[1
]}

Van Meervelt, Luc ^{[2
]}

Van der Eyckena, Erik V. ^{[1
,3
]}

机构：

[1] Katholieke Univ Leuven, Dept Chem, LOMAC, Celestijnenlaan 200F, B-3001 Leuven, Belgium

[2] Katholieke Univ Leuven, Dept Chem, Biomol Architecture, Celestijnenlaan 200F, B-3001 Leuven, Belgium

[3] RUDN Univ, Peoples Friendship Univ Russia, Miklukho Maklaya St 6, Moscow, Russia

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2019年 / 361卷 / 19期

关键词：

Annulation; C-H Activation; Rhodium; Peptidomimetic; Peptide; C-H ACTIVATION; ALPHA-AMINO-ACIDS; PALLADIUM; PEPTIDE; FUNCTIONALIZATION; TRANSFORMATIONS; CYCLIZATION; CHEMISTRY; ARYLATION; CAMPTOTHECIN;

D O I：

10.1002/adsc.201900550

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A chemoselective rhodium(III)-catalyzed cascade annulation for the construction of the indolizinone and quinolizinone scaffolds is developed. Diversification of peptidomimetics and oligopeptides is achieved in a rapid and step-economical manner through the combination of Ugi reaction and microwave-assisted rhodium(III)-catalyzed intramolecular annulation via C(sp(2))-H activation without installing a directing group.

引用

页码：4442 / 4447

页数：6

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