Residual immune activation in combined antiretroviral therapy-treated patients with maximally suppressed viremia

被引：29

作者：

Guihot, Amelie ^{[1
,2
,3
]}

Dentone, Chiara ^{[4
,5
]}

Assoumou, Lambert ^{[6
,7
]}

Parizot, Christophe ^{[2
,3
]}

Calin, Ruxandra ^{[8
]}

Seang, Sophie ^{[7
]}

Soulie, Cathia ^{[6
,7
,9
]}

Marcelin, Anne-Genevieve ^{[6
,7
,9
]}

Calvez, Vincent ^{[6
,7
,9
]}

Autran, Brigitte ^{[1
,2
,3
]}

Katlama, Christine ^{[6
,7
,8
]}

Costagliola, Dominique ^{[6
,7
]}

Carcelain, Guislaine ^{[1
,2
,3
]}

机构：

[1] Univ Paris 06, Sorbonne Univ, Paris, France

[2] INSERM, U1135, CIMI, Paris, France

[3] Hop La Pitie Salpetriere, Dept Immunol, AP HP, F-75013 Paris, France

[4] Sanremo Hosp, Dept Infect Dis, San Remo, Italy

[5] Univ Genoa, Ctr Excellence Biomed Res, I-16126 Genoa, Italy

[6] Univ Paris 06, Sorbonne Univ, UMR S 1136, Inst Pierre Louis Epidemiol & Sante Publ, Paris, France

[7] INSERM, Inst Pierre Louis Epidemiol & Sante Publ, UMR S 1136, Paris, France

[8] Hop La Pitie Salpetriere, AP HP, Malad Infect & Trop, F-75013 Paris, France

[9] Hop La Pitie Salpetriere, AP HP, Virol Lab, F-75013 Paris, France

来源：

AIDS | 2016年 / 30卷 / 02期

关键词：

HIV-INFECTED PATIENTS; T-CELL-ACTIVATION; SOLUBLE CD14; INFLAMMATION; MECHANISMS; EXPRESSION; DISEASE; MARKERS; HAART;

D O I：

10.1097/QAD.0000000000000815

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Residual immune activation was studied in 51 HIV-infected individuals, 16 with viral load between 1 and 20copies/ml and 35 with viral load less than 1copy/ml, and compared with results in 20 healthy blood donors. Higher T-cell activation and IP-10/CXCL10, MIG/CXCL9 and sCD14 plasma levels persisted in both HIV+ groups. The proportion of activated HLA-DR+ CD4 T cells was inversely correlated with the CD4 nadir and the current CD4 cell counts.

引用

页码：327 / 330

页数：4

共 26 条

[1] Circulating interleukin-6 levels correlate with residual HIV viraemia and markers of immune dysfunction in treatment-controlled HIV-infected patients [J].

Bastard, Jean-Philippe ;

Soulie, Cathia ;

Fellahi, Soraya ;

Haim-Boukobza, Stephanie ;

Simon, Anne ;

Katlama, Christine ;

Calvez, Vincent ;

Marcelin, Anne-Genevieve ;

Capeau, Jacqueline .

ANTIVIRAL THERAPY, 2012, 17 (05) :915-919

[2]

Benito JM, 2004, AIDS RES HUM RETROV, V20, P227, DOI 10.1089/088922204773004950

[3] Switch to maraviroc/raltegravir dual therapy leads to an unfavorable immune profile with low-level HIV viremia [J].

Campillo-Gimenez, Laure ;

Assoumou, Lambert ;

Valantin, Marc-Antoine ;

Pajanirassa, Priyadharshini ;

Villemonteix, Juliette ;

Soulie, Cathia ;

Marcelin, Anne-Genevieve ;

Costagliola, Dominique ;

Capeau, Jacqueline ;

Autran, Brigitte ;

Katlama, Christine ;

Guihot, Amelie .

AIDS, 2015, 29 (07) :853-856

[4] HIV-Associated Immune Activation: From Bench to Bedside [J].

d'Ettorre, Gabriella ;

Paiardini, Mirko ;

Ceccarelli, Giancarlo ;

Silvestri, Guido ;

Vullo, Vincenzo .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2011, 27 (04) :355-364

[5] Characteristics of non-AIDS-defining malignancies in the HAART era: a clinico-epidemiological study [J].

Dauby, Nicolas ;

De Wit, Stephane ;

Delforge, Marc ;

Necsoi, Valentina Coca ;

Clumeck, Nathan .

JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 2011, 14

[6] HIV Infection, Inflammation, Immunosenescence, and Aging [J].

Deeks, Steven G. .

ANNUAL REVIEW OF MEDICINE, VOL 62, 2011, 2011, 62 :141-155

[7]

Deeks Steven G, 2009, Top HIV Med, V17, P118

[8] HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity [J].

Deeks, Steven G. ;

Phillips, Andrew N. .

BMJ-BRITISH MEDICAL JOURNAL, 2009, 338 :288-292

[9] Innate immunity cell activation in virologically suppressed HIV-infected maraviroc-treated patients [J].

Dentone, Chiara ;

Di Biagio, Antonio ;

Parodi, Alessia ;

Bozzano, Federica ;

Fraccaro, Paolo ;

Signori, Alessio ;

Cenderello, Giovanni ;

Mantia, Eugenio ;

Orofino, Giancarlo ;

De Maria, Andrea ;

Filaci, Gilberto ;

Fenoglio, Daniela .

AIDS, 2014, 28 (07) :1071-1074

[10] Relationships Between Inflammation, Immune Activation, and Bone Health Among HIV-Infected Adults on Stable Antiretroviral Therapy [J].

Erlandson, Kristine M. ;

O'Riordan, MaryAnn ;

Labbato, Danielle ;

McComsey, Grace A. .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2014, 65 (03) :290-298

← 1 2 3 →