Multifunctional Platform Based on Electrospun Nanofibers and Plasmonic Hydrogel: A Smart Nanostructured Pillow for Near-Infrared Light-Driven Biomedical Applications

被引:98
作者
Nakielski, Pawel [1 ]
Pawlowska, Sylwia [1 ]
Rinoldi, Chiara [1 ]
Ziai, Yasamin [1 ]
De Sio, Luciano [2 ,3 ]
Urbanek, Olga [4 ]
Zembrzycki, Krzysztof [1 ]
Pruchniewski, Michal [1 ]
Lanzi, Massimiliano [5 ]
Salatelli, Elisabetta [5 ]
Calogero, Antonella [2 ,3 ]
Kowalewski, Tomasz A. [1 ]
Yarin, Alexander L. [6 ]
Pierini, Filippo [1 ]
机构
[1] Polish Acad Sci, Inst Fundamental Technol Res, Dept Biosyst & Soft Matter, PL-02106 Warsaw, Poland
[2] Sapienza Univ Rome, Res Ctr Biophoton, I-04100 Latina, Italy
[3] Sapienza Univ Rome, Dept Med Surg Sci & Biotechnol, I-04100 Latina, Italy
[4] Polish Acad Sci, Inst Fundamental Technol Res, Lab Polymers & Biomat, PL-02106 Warsaw, Poland
[5] Univ Bologna, Dept Ind Chem Toso Montanari, Alma Mater Studiorum, I-40136 Bologna, Italy
[6] Univ Illinois, Dept Mech & Ind Engn, Chicago, IL 60607 USA
关键词
Bioinspired materials; NIR-light responsive nanomaterials; multifunctional platforms; electrospun nanofibers; plasmonic hydrogel; photothermal-based polytherapy; on-demand drug delivery; DRUG-RELEASE; PHASE-TRANSITION; SUPRAMOLECULAR HYDROGELS; NANOCOMPOSITE HYDROGELS; MECHANICAL-PROPERTIES; RESPONSIVE HYDROGELS; POLY(LACTIC ACID); DELIVERY; POLY(N-ISOPROPYLACRYLAMIDE); NANOPARTICLES;
D O I
10.1021/acsami.0c13266
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Multifunctional nanomaterials with the ability to respond to near-infrared (NIR) light stimulation are vital for the development of highly efficient biomedical nanoplatforms with a polytherapeutic approach. Inspired by the mesoglea structure of jellyfish bells, a biomimetic multifunctional nanostructured pillow with fast photothermal responsiveness for NIR light-controlled on-demand drug delivery is developed. We fabricate a nanoplatform with several hierarchical levels designed to generate a series of controlled, rapid, and reversible cascade-like structural changes upon NIR light irradiation. The mechanical contraction of the nanostructured platform, resulting from the increase of temperature to 42 degrees C due to plasmonic hydrogel-light interaction, causes a rapid expulsion of water from the inner structure, passing through an electrospun membrane anchored onto the hydrogel core. The mutual effects of the rise in temperature and water flow stimulate the release of molecules from the nanofibers. To expand the potential applications of the biomimetic platform, the photothermal responsiveness to reach the typical temperature level for performing photothermal therapy (PTT) is designed. The on-demand drug model penetration into pig tissue demonstrates the efficiency of the nanostructured platform in the rapid and controlled release of molecules, while the high biocompatibility confirms the pillow potential for biomedical applications based on the NIR light-driven multitherapy strategy.
引用
收藏
页码:54328 / 54342
页数:15
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