A novel fluorescent probe with a large stokes shift for cysteine based on dicyanoisophorone

被引：23

作者：

Hou, Jiaqi

Cai, Pengfei

Wang, Chengyun

Shen, Yongjia ^{[1
]}

机构：

[1] East China Univ Sci & Technol, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 26期

基金：

中国国家自然科学基金;

关键词：

Fluorescent probe; Dicyanoisophorone; Large stokes shift; Cysteine; Cell imaging; ASSISTED ELECTROSTATIC ATTRACTION; LIVING CELLS; SELECTIVE DETECTION; HOMOCYSTEINE; GLUTATHIONE; SENSOR; QUANTIFICATION; NEUROTOXICITY; CATHEPSINS; COUMARIN;

D O I：

10.1016/j.tetlet.2018.05.057

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this work, a dicyanoisophorone-based turn-on fluorescent probe, DCIP, for highly selective and sensitive detection of cysteine was designed based on nucleophilic substitution mechanism. Moreover, compared with typical cysteine probes, DCIP showed great selectivity and sensitivity for cysteine over other amino acids including the similar structured homocysteine (Hcy) and glutathione (GSH). Further, the detection limit toward cysteine was calculated to be as low as 0.70 mu M. In addition, the utility of DCIP as a bioanalytical molecular tool was demonstrated by fluorescence imaging of biothiols in living cells. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：2581 / 2585

页数：5

共 50 条

[1] A novel dicyanoisophorone based red-emitting fluorescent probe with a large Stokes shift for detection of hydrazine in solution and living cells
Lv, Hongshui
Sun, Haiyan
Wang, Shoujuan
Kong, Fangong
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2018, 196 : 160 - 167
[2] Dicyanoisophorone-based near-infrared fluorescent probe with large Stokes shift for the monitoring and bioimaging of hypochlorite
Gao, Yingkai
Fan, Chuanfeng
Gao, Jian
Yang, Xintong
Wang, Xiaochun
Li, Fei
Zhou, Jin
Yu, Haifeng
Huang, Yi
Shan, Yingying
Chen, Li
TALANTA, 2024, 274
[3] A novel cysteine fluorescent probe based on benzothiazole and quinoline with a large stokes shift and application in living cell and mice
Mei, Huihui
Gu, Xin
Wang, Minghui
Cai, Yonghong
Xu, Kuoxi
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 2021, 418
[4] A diazabenzoperylene derivative as ratiometric fluorescent probe for cysteine with super large Stokes shift
Wang, Shuo
Zhang, Qi
Chen, Shaojin
Wang, Kun-Peng
Hu, Zhi-Qiang
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2020, 412 (11) : 2687 - 2696
[5] A diazabenzoperylene derivative as ratiometric fluorescent probe for cysteine with super large Stokes shift
Shuo Wang
Qi Zhang
Shaojin Chen
Kun-Peng Wang
Zhi-Qiang Hu
Analytical and Bioanalytical Chemistry, 2020, 412 : 2687 - 2696
[6] A novel fluorescent probe for selective imaging of cellular cysteine with large Stokes shift and high quantum yield
Gan, Yabing
Yin, Guoxing
Yu, Ting
Zhang, Youyu
Li, Haitao
Yin, Peng
TALANTA, 2020, 210
[7] A novel cysteine fluorescent probe with large stokes shift for imaging in living cells, zebrafish and living mice
Guo, Rui
Liu, Qing
Tang, Yonghe
Cai, Shushun
Li, Xiaoya
Gong, Xi
Yang, Yingjie
Lin, Weiying
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2022, 276
[8] Dicyanoisophorone-based fluorescent probe with large Stokes shift for ratiometric detection and imaging of exogenous/endogenous hypochlorite in cell and zebrafish
Kong, Xiang-yu
Shuang, Shao-Min
Zhang, Yue-tao
Wang, Yu
Dong, Chuan
Talanta, 2022, 242
[9] Near-infrared fluorescent probe with a super large Stokes shift for tracking CO in living systems based on a novel coumarin-dicyanoisophorone hybrid
Deng, Yingzhen
Hong, Jiaxin
Zhou, Enbo
Feng, Guoqiang
DYES AND PIGMENTS, 2019, 170
[10] Dicyanoisophorone-based fluorescent probe with large Stokes shift for ratiometric detection and imaging of exogenous/endogenous hypochlorite in cell and zebrafish
Kong, Xiang-yu
Shuang, Shao-Min
Zhang, Yue-tao
Wang, Yu
Dong, Chuan
TALANTA, 2022, 242

← 1 2 3 4 5 →