Oral immunotherapy with antigenicity-modified casein induces desensitization in cow's milk allergy

被引：6

作者：

Kawamoto, Norio ^{[1
]}

Kaneko, Hideo ^{[2
]}

Kawamoto, Minako ^{[1
]}

Ohnishi, Hidenori ^{[1
]}

Matsui, Eiko ^{[1
]}

Teramoto, Takahide ^{[1
]}

Kato, Zenichiro ^{[1
]}

Fukao, Toshiyuki ^{[1
]}

Ueno, Hiroshi M. ^{[3
]}

Nakano, Taku ^{[3
]}

Kondo, Naomi ^{[1
,4
]}

机构：

[1] Gifu Univ, Grad Sch Med, Dept Pediat, Yanagido 1-1, Gifu 5011194, Japan

[2] Nagara Med Ctr, Natl Hosp Org, Dept Clin Res, Gifu, Japan

[3] Bean Stalk Snow Co Ltd, Res & Dev Dept, Kawagoe, Saitama, Japan

[4] Heisei Coll Hlth Sci, Gifu, Japan

来源：

ALLERGY | 2020年 / 75卷 / 01期

关键词：

D O I：

10.1111/all.13965

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

It is relatively difficult to achieve clinical tolerance via OIT with cow's milk. In food allergy, immunotherapy using T-cell-tolerizing peptides is not well established. A novel antigenicity-modified form of cow's milk casein can be digested to avoid cross-reaction with IgE and retain the T-cell reaction.

引用

收藏

页码：197 / 200

页数：4

相关论文

共 9 条

[1] Japanese guidelines for food allergy 2017 [J].

Ebisawa, Motohiro ;

Ito, Komei ;

Fujisawa, Takao .

ALLERGOLOGY INTERNATIONAL, 2017, 66 (02) :248-264

[2] Novel approaches and perspectives in allergen immunotherapy [J].

Hoffmann, H. J. ;

Valovirta, E. ;

Pfaar, O. ;

Moingeon, P. ;

Schmid, J. M. ;

Skaarup, S. H. ;

Cardell, L. -O. ;

Simonsen, K. ;

Larche, M. ;

Durham, S. R. ;

Sorensen, P. .

ALLERGY, 2017, 72 (07) :1022-1034

[3] Active treatment for food allergy [J].

Kobernick, Aaron K. ;

Burks, A. Wesley .

ALLERGOLOGY INTERNATIONAL, 2016, 65 (04) :388-395

[4]

Sampson HA, 2003, PEDIATRICS, V111, P1601

[5] Clinical Studies in Oral Allergen-Specific Immunotherapy: Differences among Allergens [J].

Sato, Sakura ;

Yanagida, Noriyuki ;

Ogura, Kiyotake ;

Imai, Takanori ;

Utsunomiya, Tomohiro ;

Iikura, Katsuhito ;

Goto, Makiko ;

Asaumi, Tomoyuki ;

Okada, Yu ;

Koike, Yumi ;

Shukuya, Akinori ;

Ebisawa, Motohiro .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2014, 164 (01) :1-9

[6] Humoral and cellular responses to cow milk proteins in patients with milk-induced IgE-mediated and non-IgE-mediated disorders [J].

Shek, LPC ;

Bardina, L ;

Castro, R ;

Sampson, HA ;

Beyer, K .

ALLERGY, 2005, 60 (07) :912-919

[7] Food allergy [J].

Sicherer, Scott H. ;

Sampson, Hugh A. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 125 (02) :S116-S125

[8] Hypoallergenic casein hydrolysate for peptide-based oral immunotherapy in cow's milk allergy [J].

Ueno, Hiroshi M. ;

Kato, Teruhiko ;

Ohnishi, Hidenori ;

Kawamoto, Norio ;

Kato, Zenichiro ;

Kaneko, Hideo ;

Kondo, Naomi ;

Nakano, Taku .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2018, 142 (01) :330-333

[9] T-cell epitope-containing hypoallergenic β-lactoglobulin for oral immunotherapy in milk allergy [J].

Ueno, Hiroshi M. ;

Kato, Teruhiko ;

Ohnishi, Hidenori ;

Kawamoto, Norio ;

Kato, Zenichiro ;

Kaneko, Hideo ;

Kondo, Naomi ;

Nakano, Taku .

PEDIATRIC ALLERGY AND IMMUNOLOGY, 2016, 27 (08) :818-824