Non-haemolytic and non-pigmented group b streptococcus, an infrequent cause of early onset neonatal sepsis

被引：8

作者：

Rodriguez-Granger, Javier ^{[1
]}

Spellerberg, Barbara ^{[2
,3
]}

Asam, Daniela ^{[2
,3
]}

Rosa-Fraile, Manuel ^{[1
]}

机构：

[1] Univ Hosp Virgen de las Nieves, Microbiol, Granada 18014, Spain

[2] Univ Hosp Ulm, Inst Med Microbiol, D-89081 Ulm, Germany

[3] Univ Hosp Ulm, Hosp Hyg, D-89081 Ulm, Germany

来源：

PATHOGENS AND DISEASE | 2015年 / 73卷 / 09期

关键词：

Streptococcus agalactiae; GBS; neonatal sepsis; GBS haemolysin; AGALACTIAE; HEMOLYSIN; COLONIZATION; PIGMENT; DISEASE;

D O I：

10.1093/femspd/ftv089

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The haemolysin of Group B streptococci (GBS), a leading cause of neonatal infections, is a key virulence factor that has been implicated in the development of invasive infection. The frequency of non-haemolytic (NH) GBS isolates is around 5% among GBS carriers. To determine if similar rates are observed among invasive strains, we evaluated the incidence of NH strains among 199 GBS strains isolated from neonatal blood cultures (first week of life). Overall, we found two (1%) NH strains. This finding suggests that the frequency of NH GBS strains causing early onset invasive neonatal infection is lower than the reported frequency of NH GBS among colonizing strains.

引用

页数：3

共 20 条

[1] Epidemiology of Streptococcus agalactiae colonization in Germany [J].

Brimil, N ;

Barthell, E ;

Heindrichs, U ;

Kuhn, M ;

Lütticken, R ;

Spellerberg, B .

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2006, 296 (01) :39-44

[2] Group B streptococcal β-hemolysin/cytolysin promotes invasion of human lung epithelial cells and the release of interleukin-8 [J].

Doran, KS ;

Chang, JCW ;

Benoit, VM ;

Eckmann, L ;

Nizet, V .

JOURNAL OF INFECTIOUS DISEASES, 2002, 185 (02) :196-203

[3]

Edwards M.S., 2011, Infectious Diseases of the Fetus and Newborn Infant, P419, DOI [10.1016/B978-1-4160-6400-8.00012-2, DOI 10.1016/B978-1-4160-6400-8.00012-2]

[4] Comparison of culture with two different qPCR assays for detection of rectovaginal carriage of Streptococcus agalactiae (group B streptococci) in pregnant women [J].

El Aila, Nabil Abdullah ;

Tency, Inge ;

Claeys, Geert ;

Verstraelen, Hans ;

Deschaght, Pieter ;

Decat, Ellen ;

Santiago, Guido Lopes dos Santos ;

Cools, Piet ;

Temmerman, Marleen ;

Vaneechoutte, Mario .

RESEARCH IN MICROBIOLOGY, 2011, 162 (05) :499-505

[5] Transport of multidrug resistance substrates by the Streptococcus agalactiae hemolysin transporter [J].

Gottschalk, Birgit ;

Broeker, Gerd ;

Kuhn, Melanie ;

Aymanns, Simone ;

Gleich-Theurer, Ute ;

Spellerberg, Barbara .

JOURNAL OF BACTERIOLOGY, 2006, 188 (16) :5984-5992

[6] Comparative evaluation of 5 different selective media for Group B Streptococcus screening in pregnant women [J].

Joubrel, Caroline ;

Gendron, Nicolas ;

Dmytruk, Nicolas ;

Touak, Gerald ;

Verlaguet, Martine ;

Poyart, Claire ;

Reglier-Poupet, Helene .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2014, 80 (04) :282-284

[7] Possible Solution to the Problem of Nonhemolytic Group B Streptococcus on Granada Medium [J].

Nickmans, Silvie ;

Verhoye, Eline ;

Boel, An ;

Van Vaerenbergh, Kristien ;

De Beenhouwer, Hans .

JOURNAL OF CLINICAL MICROBIOLOGY, 2012, 50 (03) :1132-1133

[8] Group B Streptococcus β-hemolysin/Cytolysin Breaches Maternal-Fetal Barriers to Cause Preterm Birth and Intrauterine Fetal Demise in Vivo [J].

Randis, Tara M. ;

Gelber, Shari E. ;

Hooven, Thomas A. ;

Abellar, Rosanna G. ;

Akabas, Leor H. ;

Lewis, Emma L. ;

Walker, Lindsay B. ;

Byland, Leah M. ;

Nizet, Victor ;

Ratner, Adam J. .

JOURNAL OF INFECTIOUS DISEASES, 2014, 210 (02) :265-273

[9] Prevention of group B streptococcal neonatal disease revisited. The DEVANI European project [J].

Rodriguez-Granger, J. ;

Alvargonzalez, J. C. ;

Berardi, A. ;

Berner, R. ;

Kunze, M. ;

Hufnagel, M. ;

Melin, P. ;

Decheva, A. ;

Orefici, G. ;

Poyart, C. ;

Telford, J. ;

Efstratiou, A. ;

Killian, M. ;

Krizova, P. ;

Baldassarri, L. ;

Spellerberg, B. ;

Puertas, A. ;

Rosa-Fraile, M. .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2012, 31 (09) :2097-2104

[10] Granadaene:: Proposed structure of the group B streptococcus polyenic pigment [J].

Rosa-Fraile, Manuel ;

Rodriguez-Granger, Javier ;

Haidour-Benamin, Ali ;

Manuel Cuerva, Juan ;

Sampedro, Antonio .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2006, 72 (09) :6367-6370

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