A Review of Stem Cell Therapy for Spinal Cord Injury: Large Animal Models and the Frontier in Humans

被引：24

作者：

Gabel, Brandon C. ^{[1
]}

Curtis, Erik I. ^{[1
]}

Marsala, Martin ^{[1
]}

Ciacci, Joseph D. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Neurosurg, San Diego, CA 92103 USA

来源：

WORLD NEUROSURGERY | 2017年 / 98卷

关键词：

Direct injection; Mesenchymal; Neuron; Spinal cord injury; Stem cell; BONE-MARROW; FUNCTIONAL RECOVERY; CANINE MODEL; TRANSPLANTATION; BLOOD;

D O I：

10.1016/j.wneu.2016.11.053

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

OBJECTIVE: To review the literature of spinal cord injury and stem cell therapy for large animal models and incorporate those results into an understanding of stem cell therapy for human cord injury. METHODS: Review of the literature. RESULTS: Eleven canine studies were identified and 3 sub-human primate studies were identified showing variable results. CONCLUSIONS: Stem cell therapy is a promising therapeutic option for patients with spinal cord injury; however, the technology has many un-answered questions and further research is needed.

引用

页码：438 / 443

页数：6

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