The therapeutic potential of metformin in gastric cancer

被引：29
作者：
Courtois, Sarah [1 ]
Lehours, Philippe [1 ,2 ]
Bessede, Emilie [1 ,2 ]
机构：
[1] Univ Bordeaux, INSERM, UMR1053, Bordeaux Res Translat Oncol,BaRITOn, F-33000 Bordeaux, France
[2] Univ Hosp Bordeaux, French Natl Reference Ctr Campylobacters & Helico, Bordeaux, France
来源：
GASTRIC CANCER | 2019年 / 22卷 / 04期
关键词：
Gastric adenocarcinoma; EMT; Tumour growth; Cancer stem cells; ACTIVATED PROTEIN-KINASE; IN-VITRO; MOLECULAR-MECHANISMS; CELL-PROLIFERATION; STEM-CELLS; RISK; GLUCONEOGENESIS; INHIBITION; SUPPRESSES; CISPLATIN;
D O I：
10.1007/s10120-019-00952-w
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Metformin is a biguanide molecule used since 1957 to treat type 2 diabetes patients. In addition to its hypoglycemic effects, epidemiological studies have shown that metformin can be associated with a decrease in cancer development risk in diabetic populations. Thus, since 2005 this molecule is largely studied for its antitumoural properties in different types of cancer. The potential antitumoural effect of metformin in gastric cancer has been poorly studied. Here, we detailed the different described mechanisms implicated in the antitumoural effect of metformin in gastric cancer, from the signalling pathways to the functional effects on gastric cancer cell lines and gastric cancer stem cells.
引用
收藏
页码：653 / 662
页数：10
相关论文
共 65 条
[1]   Gastric Cancer, Version 3.2016 [J].
Ajani, Jaffer A. ;
D'Amico, Thomas A. ;
Almhanna, Khaldoun ;
Bentrem, David J. ;
Chao, Joseph ;
Das, Prajnan ;
Denlinger, Crystal S. ;
Fanta, Paul ;
Farjah, Farhood ;
Fuchs, Charles S. ;
Gerdes, Hans ;
Gibson, Michael ;
Glasgow, Robert E. ;
Hayman, James A. ;
Hochwald, Steven ;
Hofstetter, Wayne L. ;
Ilson, David H. ;
Jaroszewski, Dawn ;
Johung, Kimberly L. ;
Keswani, Rajesh N. ;
Kleinberg, Lawrence R. ;
Korn, W. Michael ;
Leong, Stephen ;
Linn, Catherine ;
Lockhart, A. Craig ;
Ly, Quan P. ;
Mulcahy, Mary F. ;
Orringer, Mark B. ;
Perry, Kyle A. ;
Poultsides, George A. ;
Scott, Walter J. ;
Strong, Vivian E. ;
Washington, Mary Kay ;
Weksler, Benny ;
Willett, Christopher G. ;
Wright, Cameron D. ;
Zelman, Debra ;
McMillian, Nicole ;
Sundar, Hema .
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2016, 14 (10) :1286-1312
[2]  
[Anonymous], CANC TOD
[3]  
[Anonymous], ONCOL REP
[4]  
Bailey Clifford J., 2017, DIABETOLOGIA
[5]   Metformin Inhibits Cell Proliferation, Migration and Invasion by Attenuating CSC Function Mediated by Deregulating miRNAs in Pancreatic Cancer Cells [J].
Bao, Bin ;
Wang, Zhiwei ;
Ali, Shadan ;
Ahmad, Aamir ;
Azmi, Asfar S. ;
Sarkar, Sanila H. ;
Banerjee, Sanjeev ;
Kong, Dejuan ;
Li, Yiwei ;
Thakur, Shivam ;
Sarkar, Fazlul H. .
CANCER PREVENTION RESEARCH, 2012, 5 (03) :355-364
[6]   HNF4α is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer [J].
Chang, Hae Ryung ;
Nam, Seungyoon ;
Kook, Myeong-Cherl ;
Kim, Kyung-Tae ;
Liu, Xiuping ;
Yao, Hui ;
Jung, Hae Rim ;
Lemos, Robert, Jr. ;
Seo, Hye Hyun ;
Park, Hee Seo ;
Gim, Youme ;
Hong, Dongwan ;
Huh, Iksoo ;
Kim, Young-Woo ;
Tan, Dongfeng ;
Liu, Chang-Gong ;
Powis, Garth ;
Park, Taesung ;
Liang, Han ;
Kim, Yon Hui .
GUT, 2016, 65 (01) :19-+
[7]  
Chen GX, 2015, AM J CANCER RES, V5, P1423
[8]   Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development [J].
Chia, Na-Yu ;
Deng, Niantao ;
Das, Kakoli ;
Huang, Dachuan ;
Hu, Longyu ;
Zhu, Yansong ;
Lim, Kiat Hon ;
Lee, Ming-Hui ;
Wu, Jeanie ;
Sam, Xin Xiu ;
Tan, Gek San ;
Wan, Wei Keat ;
Yu, Willie ;
Gan, Anna ;
Tan, Angie Lay Keng ;
Tay, Su-Ting ;
Soo, Khee Chee ;
Wong, Wai Keong ;
Dominguez, Lourdes Trinidad M. ;
Ng, Huck-Hui ;
Rozen, Steve ;
Goh, Liang-Kee ;
Teh, Bin-Tean ;
Tan, Patrick .
GUT, 2015, 64 (05) :707-719
[9]  
Chiurillo MA., 2015, World J Expert Med, V5, P84, DOI [DOI 10.5493/WJEM.V5.I2.84, 10.5493/wjem.v5.i2.84]
[10]   Metformin can inhibit Helicobacter pylori growth [J].
Courtois, Sarah ;
Benejat, Lucie ;
Izotte, Julien ;
Megraud, Francis ;
Varon, Christine ;
Lehours, Philippe ;
Bessede, Emilie .
FUTURE MICROBIOLOGY, 2018, 13 (14) :1575-1584
1234567