A Robust Minimax Semidefinite Programming Formulation for Optimal Design of Experiments for Model Parametrization

Model-based optimal design of experiments (M-bODE) is a crucial step in model parametrization since it encloses a framework that maximizes the amount of information extracted from a battery of lab experiments. We address the design of M-bODE for dynamic models considering a continuous representation of the design. We use Semidefinite Programming (SDP) to derive robust minmax formulations for nonlinear models, and extend the formulations to other criteria. The approaches are demonstrated for a CSTR where a two-step reaction occurs.