Differentiation and growth inhibition mediated via the RXR:PPARγ heterodimer in colon cancer

被引：73

作者：

Cesario, Rosemary M. ^{[1
]}

Stone, Jessica ^{[1
]}

Yen, Wan-Ching ^{[1
]}

Bissonnette, Reid P. ^{[1
]}

Lamph, William W. ^{[1
]}

机构：

[1] Ligand Pharmaceut, Dept Mol Oncol, San Diego, CA 92121 USA

来源：

CANCER LETTERS | 2006年 / 240卷 / 02期

关键词：

colon cancer; RXR; PPAR; differentiation induction; growth inhibition;

D O I：

10.1016/j.canlet.2005.09.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study evaluated the anti-tumor efficacy of combining the RXR agonist, bexarotene, with the PPAR gamma agonist, rosiglitazone, in colon cancer. Moser, a human colon cancer cell line, was treated with bexarotene and rosiglitazone alone or in combination and the effect on growth and differentiation were examined. The data demonstrated that the bexarotene/rosiglitazone combination produced greater efficacy in growth inhibition than either single agent. Furthermore, combination treatment acted cooperatively to decrease COX-2 expression and PGE2 synthesis while increasing expression of the differentiation marker, CEA. These findings were confirmed in vivo in a Moser xenograft tumor model. Collectively, our data suggest a potential role for utilizing a combination regimen of a RXR and PPAR gamma agonist in the treatment of colon cancer. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：225 / 233

页数：9

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