Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques

被引：240

作者：

Hazuda, DJ

Young, SD

Guare, JP

Anthony, NJ

Gomez, RP

Wai, JS

Vacca, JP

Handt, L

Motzel, SL

Klein, HJ

Dornadula, G

Danovich, RM

Witmer, MV

Wilson, KAA

Tussey, L

Schleif, WA

Gabryelski, LS

Jin, LX

Miller, MD

Casimiro, DR

Emini, EA

Shiver, JW

机构：

[1] Merck Res Labs, Dept Biol Chem, W Point, PA 19486 USA

[2] Merck Res Labs, Dept Med Chem, W Point, PA 19486 USA

[3] Merck Res Labs, Dept Lab Anim Res, W Point, PA 19486 USA

[4] Merck Res Labs, Dept Vaccine Res, W Point, PA 19486 USA

[5] Merck Res Labs, Dept Drug Metab & Pharmaceut Res, W Point, PA 19486 USA

来源：

SCIENCE | 2004年 / 305卷 / 5683期

关键词：

D O I：

10.1126/science.1098632

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We describe the efficacy of L-870812, an inhibitor of HIV-1 and SIV integrase, in rhesus macaques infected with the simian-human immunodeficiency virus (SHIV) 89.6P. When initiated before CD4 cell depletion, L-870812 therapy mediated a sustained suppression of viremia, preserving CD4 levels and permitting the induction of virus-specific cellular immunity. L-870812 was also active in chronic infection; however, the magnitude and durability of the effect varied in conjunction with the pretreatment immune response and viral load. These studies demonstrate integrase inhibitor activity in vivo and suggest that cellular immunity facilitates chemotherapeutic efficacy in retroviral infections.

引用

页码：528 / 532

页数：5

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