Zebrafish as a model to study live mucus physiology

被引：54

作者：

Jevtov, Irena ^{[1
]}

Samuelsson, Tore ^{[2
]}

Yao, Grace ^{[1
]}

Amsterdam, Adam ^{[3
]}

Ribbeck, Katharina ^{[1
]}

机构：

[1] MIT, Dept Biol Engn, Cambridge, MA 02139 USA

[2] Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Med Biochem & Cell Biol, Gothenburg, Sweden

[3] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

来源：

SCIENTIFIC REPORTS | 2014年 / 4卷

关键词：

HUMAN MUCIN GENES; SALIVARY MUCINS; EXPRESSION; PROTECTION; TRACT; ORGANIZATION; AIRWAYS;

D O I：

10.1038/srep06653

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dysfunctional mucus barriers can result in important pulmonary and gastrointestinal conditions, but model systems to study the underlying causes are largely missing. We identified and characterized five mucin homologues in zebrafish, and demonstrated a strategy for fluorescence labeling of one selected mucin. These tools can be used for in vivo experiments and in pharmacological and genetic screens to study the dynamics and mechanisms of mucosal physiology.

引用

页数：6

共 46 条

[1] Salivary mucins: Protective functions in relation to their diversity [J].