Curcumin induces apoptosis of HepG2 cells via inhibiting fatty acid synthase

被引：66
作者：
Fan, Huijin [1 ,2 ]
Tian, Weixi [1 ]
Ma, Xiaofeng [1 ]
机构：
[1] Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China
[2] Natl Res Inst Family Planning, Beijing 100081, Peoples R China
来源：
TARGETED ONCOLOGY | 2014年 / 9卷 / 03期
关键词：
Fatty acid synthase; Inhibitor; Curcumin; HepG2; cells; Cell apoptosis; CANCER-CELLS; MOLECULAR TARGETS; EPIGALLOCATECHIN GALLATE; ANTITUMOR-ACTIVITY; NATURAL INHIBITOR; PROSTATE-CANCER; GENE-PRODUCTS; LUNG-CANCER; EXPRESSION; PROLIFERATION;
D O I：
10.1007/s11523-013-0286-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Fatty acid synthase (FAS) is highly expressed in many kinds of human cancers, including liver cancer. Curcumin is the major active ingredient of Curcuma longa and has long been used to treat a variety of maladies. In the present study, we investigated the potential use of curcumin as a kind of FAS inhibitor for chemoprevention of liver cancer. Curcumin induced HepG2 cell apoptosis with the IC50 value of 8.84 mu g/ml. It inhibited intracellular FAS activity, and downregulated expression and mRNA level of FAS in a dose-dependent manner. In addition, sodium palmitate could rescue cell apoptosis induced by curcumin. Further studies reviewed that siRNA of FAS showed similar results as curcumin. These findings suggested that curcumin might be useful for preventing or treating liver cancer.
引用
收藏
页码：279 / 286
页数：8
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