In Elimination Settings, Measles Antibodies Wane After Vaccination but Not After Infection: A Systematic Review and Meta-Analysis

被引：24

作者：

Bolotin, Shelly ^{[1
,2
,3
,4
]}

Osman, Selma ^{[1
]}

Hughes, Stephanie L. ^{[1
]}

Ariyarajah, Archchun ^{[2
]}

Tricco, Andrea C. ^{[2
,5
,6
]}

Khan, Sumaiya ^{[1
]}

Li, Lennon ^{[1
,2
]}

Johnson, Caitlin ^{[1
]}

Friedman, Lindsay ^{[1
]}

Gul, Nazish ^{[1
]}

Jardine, Rachel ^{[1
,2
]}

Faulkner, Maryrose ^{[1
,2
]}

Hahne, Susan J. M. ^{[7
]}

Heffernan, Jane M. ^{[8
]}

Dabbagh, Alya ^{[9
]}

Rota, Paul A. ^{[10
]}

Severini, Alberto ^{[11
,12
]}

Jit, Mark ^{[13
,14
]}

Durrheim, David N. ^{[15
]}

Orenstein, Walter A. ^{[16
]}

Moss, William J. ^{[17
]}

Funk, Sebastian ^{[13
,18
]}

Turner, Nikki ^{[19
]}

Schluter, William ^{[10
]}

Jawad, Jaleela S. ^{[20
]}

Crowcroft, Natasha S. ^{[2
,3
,4
,9
]}

机构：

[1] Publ Hlth Ontario, Toronto, ON, Canada

[2] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

[3] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[4] Univ Toronto, Ctr Vaccine Preventable Dis, Toronto, ON, Canada

[5] St Michaels Hosp, Li Ka Shing Knowledge Inst, Unity Hlth Toronto, Toronto, ON, Canada

[6] Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada

[7] Natl Inst Publ Hlth & Environm, Ctr Epidemiol & Surveillance Infect Dis, Bilthoven, Netherlands

[8] York Univ, Ctr Dis Modelling, Dept Math & Stat, Toronto, ON, Canada

[9] WHO, Dept Immunisat Vaccines & Biol, Geneva, Switzerland

[10] Ctr Dis Control & Prevent, Atlanta, GA USA

[11] Publ Hlth Agcy Canada, Natl Microbiol Lab, Winnipeg, MB, Canada

[12] Univ Manitoba, Dept Med Microbiol & Infect Dis, Winnipeg, MB, Canada

[13] London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, Dept Infect Dis Epidemiol, London, England

[14] Publ Hlth England, UK Modeling & Econ Unit, Natl Infect Serv, Trop Med, London, England

[15] Univ Newcastle, Sch Med & Publ Hlth, Newcastle, NSW, Australia

[16] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA USA

[17] Johns Hopkins Univ, Int Vaccine Access Ctr, Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA

[18] London Sch Hyg & Trop Med, Ctr Math Modelling Infect Dis, London, England

[19] Univ Auckland, Dept Gen Practice & Primary Care, Auckland, New Zealand

[20] Primary Healthcare Ctr, Maqabah, Bahrain

来源：

JOURNAL OF INFECTIOUS DISEASES | 2022年 / 226卷 / 07期

关键词：

measles elimination; measles immunity; measles vaccination; waning immunity; PREVENTABLE DISEASES; RUBELLA ANTIBODIES; PERSISTENCE; MUMPS; CHILDREN; IMMUNITY; IMMUNOGENICITY; SEROPREVALENCE; IMMUNIZATION; POPULATION;

D O I：

10.1093/infdis/jiac039

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This review assesses whether humoral immunity from measles vaccine or infection wanes over time. Antibody levels in individuals receiving 2 doses of MCV declined nonlinearly over the 20 years of available data but did not fall below the protective threshold. Background We conducted a systematic review to assess whether measles humoral immunity wanes in previously infected or vaccinated populations in measles elimination settings. Methods After screening 16 822 citations, we identified 9 articles from populations exposed to wild-type measles and 16 articles from vaccinated populations that met our inclusion criteria. Results Using linear regression, we found that geometric mean titers (GMTs) decreased significantly in individuals who received 2 doses of measles-containing vaccine (MCV) by 121.8 mIU/mL (95% confidence interval [CI], -212.4 to -31.1) per year since vaccination over 1 to 5 years, 53.7 mIU/mL (95% CI, -95.3 to -12.2) 5 to 10 years, 33.2 mIU/mL (95% CI, -62.6 to -3.9), 10 to 15 years, and 24.1 mIU/mL (95% CI, -51.5 to 3.3) 15 to 20 years since vaccination. Decreases in GMT over time were not significant after 1 dose of MCV or after infection. Decreases in the proportion of seropositive individuals over time were not significant after 1 or 2 doses of MCV or after infection. Conclusions Measles antibody waning in vaccinated populations should be considered in planning for measles elimination.

引用

页码：1127 / 1139

页数：13

共 67 条

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