Sphingosylphosphorylcholine-biological functions and mechanisms of action

被引：103

作者：

Heringdorf, DMZ ^{[1
]}

Himmel, HM ^{[1
]}

Jakobs, KH ^{[1
]}

机构：

[1] Univ Klinikum Essen, Inst Pharmakol, D-45122 Essen, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2002年 / 1582卷 / 1-3期

关键词：

lysophospholipid; lipid signalling; sphingosylphosphorylcholine; sphingosine-1-phosphate; lysophosphatidylcholine; G-protein-coupled receptor;

D O I：

10.1016/S1388-1981(02)00154-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Compared to the lysophospholipid mediators, sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), little information is available regarding the molecular mechanisms of action, metabolism and physiological significance of the related sphingosylphosphorylcholine (SPC). S1P and LPA have recently been established as agonists at several G-protein-coupled receptors of the EDG family, SIP additionally serves an intracellular second messenger function. Several cellular effects of SPC can be explained by low-affinity binding to and activation of S1P-EDG receptors. However, certain cellular and subcellular actions of SPC are not shared by SIP, suggesting that SPC, which has been identified in normal blood plasma, ascites and various tissues, is a lipid mediator in its own right. This concept was corroborated by the recent discovery of specific high-affinity G-protein-coupled SPC receptors. In this article, our present knowledge on cellular actions and biological functions of SPC will be reviewed. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：178 / 189

页数：12