Chronic stress-induced changes in the rat brain: Role of sex differences and effects of long-term tianeptine treatment

被引：21

作者：

Kuipers, Sjoukje D. ^{[1
,3
]}

Trentani, Andrea ^{[1
,2
,3
]}

van der Zee, Eddy A. ^{[2
]}

den Boer, Johan A. ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, NL-9700 AB Groningen, Netherlands

[2] Univ Groningen, Ctr Behav & Neurosci, Dept Mol Neurobiol, NL-9747 AG Groningen, Netherlands

[3] Univ Bergen, Dept Biomed, N-5009 Bergen, Norway

来源：

NEUROPHARMACOLOGY | 2013年 / 75卷

关键词：

BrdU; Chronic stress; CREB phosphorylation; FOS expression; Sex differences; Tianeptine; C-FOS EXPRESSION; ANTIDEPRESSANT TIANEPTINE; HIPPOCAMPAL NEUROGENESIS; GLUCOCORTICOID-RECEPTOR; CELL-PROLIFERATION; PREFRONTAL CORTEX; GENDER; DEPRESSION; PLASTICITY; RESPONSES;

D O I：

10.1016/j.neuropharm.2013.08.018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Growing evidence suggests neuroplasticity changes are pivotal in both the occurrence and treatment of affective disorders. Abnormal expression and/or phosphorylation of numerous plasticity-related proteins have been observed in depression, while prolonged antidepressant treatment has been associated with the attenuation of stress-mediated effects on dendritic remodeling and adult hippocampal neurogenesis in experimental animals. This study explores the neurobiological adaptations induced by chronic stress and/or long-term tianeptine treatment. Male and female rats were studied to determine the potential contributory role of sex differences on stress-induced pathology and antidepressant-mediated actions. Our results confirm chronic stress-induced HPA axis disturbance and neuroplasticity impairment in both sexes (i.e. reduced CREB phosphorylation and hippocampal BrdU labeling). Commonly ensuing neurobiological alterations were accompanied by unique sex-specific adaptations. When the antidepressant tianeptine was administered, HPA axis hyperactivity was attenuated and specific neuronal defects were ameliorated in both sexes. These findings provide novel insight into sex-related influences on the neurobiological substrates mediating chronic stress-induced actions on neuroplasticity and the mechanisms underlying tianeptine-mediated therapeutic effects. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：426 / 436

页数：11

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