Cytotoxic triterpenoid saponins from Ardisia pusilla

被引：13
|
作者：
Tang, Hai Feng [1 ]
Lin, Hou Wen [2 ]
Chen, Xiao Li [1 ]
Cheng, Guang [3 ]
Zhao, Yue Ping [1 ]
Wen, Ai Dong [1 ]
机构：
[1] Fourth Mil Med Univ, Dept Pharm, Xijing Hosp, Xian 710032, Peoples R China
[2] Second Mil Med Univ, Dept Pharm, Changzheng Hosp, Shanghai 200003, Peoples R China
[3] Fourth Mil Med Univ, Dept Neurosurg, Xijing Hosp, Xian 710032, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2009年 / 20卷 / 02期
关键词：
Ardisia pusilla; Triperpenoid saponin; Ardipusilloside III; Cytotoxic activities; NMR;
D O I：
10.1016/j.cclet.2008.10.030
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new triterpenoid saponin, 3-O-{beta-D-xylopyranosyl-(1 -> 2)-beta-D-glucopyranosyl-(1 -> 4)-[beta-D-glucopyranosyl-(1 -> 2)]-alpha-L-arabinopyranosyl}-3 beta,16 alpha,28 alpha-trihydroxy-13 beta,28-epoxy-oleanan-30-al(ardipusilloside III, 1), together with two known saponins, ardisiacrispins A (2) and B (3), were isolated from the whole plants of Ardisia pusilla A. DC. Their structures were elucidated by extensive spectral analysis and chemical evidences. Saponins 1 and 3 exhibited significant cytotoxicity against human glioblastoma U251MG cells.
引用
收藏
页码：193 / 196
页数：4
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