Oocyte development, meiosis and aneuploidy

被引：131

作者：

MacLennan, Marie ^{[1
]}

Crichton, James H. ^{[1
]}

Playfoot, Christopher J. ^{[1
]}

Adams, Ian R. ^{[1
]}

机构：

[1] Univ Edinburgh, Western Gen Hosp, MRC Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2015年 / 45卷

基金：

英国医学研究理事会;

关键词：

Oocyte; Meiosis; Aneuploidy; Trisomy; Recombination; Cohesion; SISTER-CHROMATID COHESION; GENOME-WIDE RECOMBINATION; MATERNAL AGE; MEIOTIC RECOMBINATION; CHROMOSOME SEGREGATION; CROSSING-OVER; NONDISJUNCTION; COMPLEXES; RNF212; FEMALE;

D O I：

10.1016/j.semcdb.2015.10.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Meiosis is one of the defining events in gametogenesis. Male and female germ cells both undergo one round of meiotic cell division during their development in order to reduce the ploidy of the gametes, and thereby maintain the ploidy of the species after fertilisation. However, there are some aspects of meiosis in the female germline, such as the prolonged arrest in dictyate, that appear to predispose oocytes to missegregate their chromosomes and transmit aneuploidies to the next generation. These maternally-derived aneuploidies are particularly problematic in humans where they are major contributors to miscarriage, age-related infertility, and the high incidence of Down's syndrome in human conceptions. This review will discuss how events that occur in foetal oocyte development and during the oocytes' prolonged dictyate arrest can influence meiotic chromosome segregation and the incidence of aneuploidy in adult oocytes. (C) 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.

引用

页码：68 / 76

页数：9

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