Citicoline Improves Human Vigilance and Visual Working Memory: The Role of Neuronal Activation and Oxidative Stress

Introduction: Psychomotor performance task is used to assess the arousal and cognitive functions of the central nervous system. Alternatively, human visual working memory reflects the capability of the individual's short-term memory. Psycho-mental stimuli are linked to the stimulation of Malondialdehyde (MDA) formations. Citicoline is a nootropic nucleotide agent with a favorable effect on the augmentation of human memory and cognitive function. Thus, the purpose of this study was to determine the effect of citicoline on human vigilance, visual working memory, and oxidative stress using healthy volunteers. Methods: 40 healthy volunteers were enrolled and divided into two groups: group A: 20 volunteers received 500mg/day starch capsule for two weeks and group B: 20 volunteers received 500mg/day citicoline capsule for two weeks. Human vigilance, visual working memory, and oxidative stress markers of each volunteer were assessed before and after citicoline and placebo intake. The obtained data were analyzed by SPSS regarding P<0.05 as statistically significant. Results: Placebo had no significant effect on human vigilance and visual working memory after two weeks of therapy (P>0.05), whereas citicoline improved most variables of psychomotor performances and working memory (P<0.01). Placebo significantly increased serum MDA levels from 19.44 +/- 2.11 to 29.66 +/- 3.28 nmol/mL (P=0.0001), while citicoline significantly decreased MDA serum levels from 19.11 +/- 2.66 to 15.63 +/- 1.33 nmol/mL (P=0.0001). Conclusion: Citicoline improves human psychomotor vigilance, arousal, and visual working memory with significant amelioration of oxidative stress comparedwith placebo. Highlights Citicoline improves human psychomotor performances and working memory accuracy. Citicoline attenuates high vigilance induced-oxidative stress. Citicoline provokes cognitive functions in normal healthy volunteers. Plain Language Summary Citicoline is a nootropic nucleotide agent with a positive effect on the conservation of the neurons and augmentation of human memory and cognitive functions. We examined the effect of citicoline on psychomotor performances and working memory accuracy in relation to the oxidative stress in healthy volunteers. Our results demonstrated that citicoline advances psychomotor performances and working memory precision with the noteworthy lessening of oxidative stress compared with controls in both genders.