Estrogen receptor α gene PvuII polymorphism and coronary artery disease: a meta-analysis of 21 studies

被引：15

作者：

Ding, Jie ^{[1
]}

Xu, Hui ^{[2
]}

Yin, Xiang ^{[1
]}

Zhang, Fu-rong ^{[1
]}

Pan, Xiao-ping ^{[3
]}

Gu, Yi-an ^{[4
]}

Chen, Jun-zhu ^{[1
]}

Guo, Xiao-gang ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Cardiol, Hangzhou 310003, Zhejiang, Peoples R China

[2] Gaozhao St Community Hlth Serv Ctr, Jiaxing 314031, Peoples R China

[3] Zhejiang Univ, Sch Med, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis, Hangzhou 310003, Zhejiang, Peoples R China

[4] Columbia Univ, Med Ctr, New York, NY 10032 USA

来源：

JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B | 2014年 / 15卷 / 03期

关键词：

Estrogen receptor alpha gene; Polymorphism; Meta-analysis; Coronary artery disease (CAD); POSTMENOPAUSAL WOMEN; HEART-DISEASE; CARDIOVASCULAR-DISEASE; REPLACEMENT THERAPY; RACIAL-DIFFERENCES; HORMONE-THERAPY; ASSOCIATION; CANCER; RISK; POPULATIONS;

D O I：

10.1631/jzus.B1300220

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The association between the estrogen receptor a gene (ESR1) PvuII polymorphism (c.454-397T>C) and coronary artery disease (CAD) is controversial. Thus, we conducted a meta-analysis to evaluate the relationship. Data were collected from 21 studies encompassing 9926 CAD patients and 16 710 controls. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the relationship between PvuII polymorphism and CAD. The polymorphism in control populations in all studies followed Hardy-Weinberg equilibrium. We found a significant association between ESR1 PvuII polymorphism and CAD risk in all subjects. When the data were stratified by region, a significant association between ESR1 PvuII polymorphism and CAD risk was observed in Asian populations but not in Western populations. The current study suggests that ESR1 PvuII polymorphism has an important role in CAD susceptibility.

引用

页码：243 / 255

页数：13

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