The T cell as a bridge between innate and adaptive immune systems: Implications for the kidney

被引:132
作者
Rabb, H [1 ]
机构
[1] Johns Hopkins Univ, Sch Med, Dept Med, Div Nephrol, Baltimore, MD 21205 USA
关键词
T cell; acute renal failure; ischemia reperfusion; innate immunity; adaptive immunity;
D O I
10.1046/j.1523-1755.2002.00378.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The immune system is classically divided into innate and adaptive components with distinct roles and functions. T cells are major components of the adaptive immune system. T cells are firmly established to mediate various immune-mediated kidney diseases and are current targets for therapy. Ischemic acute renal failure, a major cause of native kidney and allograft dysfunction, is mediated in part by inflammatory components of the innate immune system. However, recent data from experimental models in kidney as well as liver, intestine, brain and heart implicate T cells as important mediators of ischemia reperfusion injury. These data reveal new insights into the pathogenesis of ischemic acute renal failure, as well as identify novel and feasible therapeutic approaches. Furthermore, the identification of T cells as a mediator of early alloantigen-independent tissue injury demonstrates that the functional capacity of T cells spreads beyond adaptive immunity into the realm of the innate immune response.
引用
收藏
页码:1935 / 1946
页数:12
相关论文
共 102 条
  • [1] Functional diversity of helper T lymphocytes
    Abbas, AK
    Murphy, KM
    Sher, A
    [J]. NATURE, 1996, 383 (6603) : 787 - 793
  • [2] ABBAS AK, 2000, CELLULAR MOL IMMUNOL, P553
  • [3] ABBAS AK, 1991, CELLULAR MOL IMMUNOL, P259
  • [4] EARLY CELLULAR EVENTS IN THE LUNG ALLOGRAFT
    ADOUMIE, R
    SERRICK, C
    GIAID, A
    SHENNIB, H
    [J]. ANNALS OF THORACIC SURGERY, 1992, 54 (06) : 1071 - 1077
  • [5] Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system
    Agrawal, A
    Eastman, QM
    Schatz, DG
    [J]. NATURE, 1998, 394 (6695) : 744 - 751
  • [6] VDJ RECOMBINATION
    ALT, FW
    OLTZ, EM
    YOUNG, F
    GORMAN, J
    TACCIOLI, G
    CHEN, J
    [J]. IMMUNOLOGY TODAY, 1992, 13 (08): : 306 - 314
  • [7] ACTIVATION OF DUAL T-CELL SIGNALING PATHWAYS BY THE CHEMOKINE RANTES
    BACON, KB
    PREMACK, BA
    GARDNER, P
    SCHALL, TJ
    [J]. SCIENCE, 1995, 269 (5231) : 1727 - 1730
  • [8] A conserved signaling pathway: The Drosophila Toll-Dorsal pathway
    Belvin, MP
    Anderson, KV
    [J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1996, 12 : 393 - 416
  • [9] Endotoxin, toll-like receptor 4, and the afferent limb of innate immunity
    Beutler, B
    [J]. CURRENT OPINION IN MICROBIOLOGY, 2000, 3 (01) : 23 - 28
  • [10] An innate view of gamma delta T cells
    Boismenu, R
    Havran, WL
    [J]. CURRENT OPINION IN IMMUNOLOGY, 1997, 9 (01) : 57 - 63