Synthesis of (3R,4S,5S,9S)-3,5,9-trihydroxy-4-methylundecanoic acid δ-lactone

被引：9

作者：

Chakraborty, TK ^{[1
]}

Goswami, RK ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 41期

关键词：

(3R,4S,5S,9S)-3,5,9-trihydroxy-4-methylundecanoic acid; delta-lactone; sharpless kinetic resolution; epoxide opening; 2-methyl-1,3-diol;

D O I：

10.1016/j.tetlet.2004.08.099

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Radical-mediated opening of a chiral trisubstituted epoxy alcohol using cp(2)TiCl furnished the '2-methyl-1,3-diol' moiety with the desired stereochemistry, which led to a total synthesis of (3R,4S,5S,9S)-3,5,9-trihydroxy-4-methylundecanoic acid delta-lactone 1. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：7637 / 7639

页数：3

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