Synthesis, characterisation, cytotoxicity and radioprotective effect of novel chiral nitronyl nitroxyl radicals

被引：16

作者：

Qin, Xiang-Yang ^{[1
]}

Ding, Gui-Rong ^{[2
]}

Wang, Xiao-Wu

Tan, Juan ^{[2
]}

Guo, Guo-Zhen ^{[2
]}

Sun, Xiao-Li ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Dept Chem, Xian 710032, Shanxi, Peoples R China

[2] Fourth Mil Med Univ, Dept Radiat Med, Xian 710032, Shanxi, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH-S | 2009年 / 08期

关键词：

chiral nitronyl nitroxyl radicals; cytotoxicity; radioprotective effect; RADIATION; TEMPOL; SUPEROXIDE; PREVENTION; CHEMISTRY; ALOPECIA; ALCOHOLS; ESTERS; DAMAGE; ACID;

D O I：

10.3184/030823409X12474221035163

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nitroxyl compounds have been previously investigated as potential radioprotection drugs. To develop new radioprotectors, two kinds of novel chiral nitronyl nitroxyl radicals: L-tert-butyl 2-(4,5-dihydro-4,4,5,5- tetramethyl-3-oxido-1H-imidazol-3-ium-1-oxyl-2-yl] pyrrolidine-1-carboxylate (L-NNP) and L-tert-butyl 2-[(4-(4,5-dihydro-4,4,5,5-tetramethyl-3-oxido-1H-imidazol-3-ium-1-oxyl-2-yl)-2-methoxyphenoxy) methyl] pyrrolidine-1-carboxylate (L-NNVP) have been synthesised. The cytotoxic and radioprotective effects of these two compounds were then evaluated in rat glioma C6 cells.

引用

页码：511 / 514

页数：4

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