Precision Medicine for Idiopathic Hypersomnia

被引:32
作者
Arnulf, Isabelle [1 ]
Leu-Semenescu, Smaranda
Dodet, Pauline
机构
[1] Pitie Salpetriere Univ Hosp, AP HP, Natl Reference Ctr Rare Hypersomnias, 47-83 Blvd Hop, F-75013 Paris, France
关键词
Hypersomnia; Long sleep time; Drowsiness; GABA; Modafinil; Sodium oxybate; LONG-SLEEP TIME; QUALITY-OF-LIFE; SYMPTOMATIC HYPERSOMNIA; DOUBLE-BLIND; NARCOLEPSY; MODAFINIL; HISTAMINE; POLYSOMNOGRAPHY; PITOLISANT; CATAPLEXY;
D O I
10.1016/j.jsmc.2019.05.007
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Idiopathic hypersomnia (IH) is characterized by excessive daytime sleepiness despite normal or prolonged sleep. IH is distinguished from narcolepsy by the female predominance, severe morning inertia, continuous drowsiness (rather than sleep attacks), unrefreshing naps, absence of cataplexy, sleep onset in REM periods, and hypocretin deficiency. In IH, the multiple sleep latency test demonstrates low sensitivity, specificity, and reproducibility, compared with prolonged sleep monitoring. In some IH cases, an endogenous hypnotic peptide stimulating GABA receptors during wakefulness is suspected, which are improved by anti-GABA drugs. The benefits of modafinil, sodium oxybate, mazindol, and pitolisant were found in mostly retrospective studies.
引用
收藏
页码:333 / +
页数:20
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