Syzygium cumini (L.) skeels: a prominent source of bioactive molecules against cardiometabolic diseases

被引:60
作者
Chagas, Vinicyus Teles [1 ,2 ]
Franca, Lucas Martins [1 ,2 ]
Malik, Sonia [2 ]
de Andrade Paes, Antonio Marcus [1 ,2 ]
机构
[1] Univ Fed Maranhao, Dept Physiol Sci, Lab Expt Physiol, Sao Luis, Brazil
[2] Univ Fed Maranhao, Biol & Hlth Sci Ctr, Grad Program Hlth Sci, Sao Luis, Brazil
关键词
black plum; jamun; myrtaceae; phenolic compounds; metabolic syndrome; ethnopharmacology; medicinal plants; complementary and alternative medicine; AMELIORATES INSULIN-RESISTANCE; FLAVONOID-RICH EXTRACT; PPAR-GAMMA; PHENOLIC CONSTITUENTS; ANTIOXIDANT ACTIVITY; DIABETES-MELLITUS; OXIDATIVE STRESS; MYRTACEAE; SEEDS; ACTIVATION;
D O I
10.3389/fphar.2015.00259
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Syzygium cumini (Myrtaceae) is a worldwide medicinal plant traditionally used in herbal medicines due to its vaunted properties against cardiometabolic disorders, which include: antihyperglycemic, hypolipemiant, antiinflammatory, cardioprotective, and antioxidant activities. These properties have been attributed to the presence of bioactive compounds such as phenols, flavonoids, and tannins in different parts of the plant, albeit the knowledge on their mechanisms of action is scarce. This mini review highlights the cardiometabolic properties of S. cumini by correlating its already identified phytochemicals with their described mechanisms of action. Data herein compiled show that some compounds target multiple metabolic pathways; thereby, becoming potential pharmacological tools. Moreover, the lack of clinical trials on S. cumini usage makes it a fruitful field of interest for both scientific community and pharmaceutical industry.
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页数:8
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