Patient reported outcome measures among patients with vulvar cancer at various stages of treatment, recurrence, and survivorship

被引：17

作者：

Alimena, Stephanie ^{[1
,2
]}

Sullivan, Mackenzie W. ^{[1
,2
]}

Philp, Lauren ^{[1
]}

Dorney, Katelyn ^{[1
]}

Hubbell, Harrison ^{[1
]}

del Carmen, Marcela G. ^{[1
]}

Goodman, Annekathryn ^{[1
]}

Bregar, Amy ^{[1
]}

Growdon, Whitfield B. ^{[1
]}

Eisenhauer, Eric L. ^{[1
]}

Sisodia, Rachel Clark ^{[1
]}

机构：

[1] Harvard Med Sch, Massachusetts Gen Hosp, Div Gynecol Oncol, Vincent Obstet & Gynecol, Boston, MA USA

[2] Harvard Med Sch, Brigham & Womens Hosp, Div Gynecol Oncol, Dept Obstet Gynecol & Reprod Biol, Boston, MA USA

来源：

GYNECOLOGIC ONCOLOGY | 2021年 / 160卷 / 01期

关键词：

Patient reported outcomes; Vulvar cancer; Survivors; Recurrence; QUALITY-OF-LIFE; GYNECOLOGIC-ONCOLOGY; CLINICAL-USE; WOMEN; NEOPLASIA; SURVIVAL; PRIMER;

D O I：

10.1016/j.ygyno.2020.10.022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective. Our goal was to pragmatically describe patient reported outcomes (PROs) in a typical clinic population of vulvar cancer patients, as prior studies of vulvar cancer PROs have examined clinical trial participants. Methods. A prospective PRO program was implemented in the Gynecologic Oncology clinic of a tertiary academic institution in January 2018. Vulvar cancer patients through September 2019 were administered the European Organization for the Research and Treatment of Cancer Quality of life Questionnaire, the Patient Reported Outcome Measurement Information System Instrumental and Emotional Support Scales, and the Functional Assessment of Cancer Therapy-Vulvar questionnaire. Binary logistic regressions were performed to determine adjusted odds ratios for adverse responses to individual questions by insurance, stage, age, time since diagnosis, recurrence, radiation, and surgical radicality. Results. Seventy vulvar cancer patients responded to PROs (85.4% response rate). Seventy-one percent were > 1 year since diagnosis, 61.4% had stage I disease, and 28.6% recurred. Publicly insured women had less support and worse quality of life (QOL, aOR 4.15, 95% CI 1.00-17.32, p = 0.05). Women who recurred noted more interference with social activities (aOR 4.45, 95% CI 1.28-15.41, p = 0.019) and poorer QOL (aOR 5.22 95% CI 1.51-18.10, p = 0.009). There were no major differences by surgical radicality. Those >1 year since diagnosis experienced less worry (aOR 0.17, 95% CI 0.04-0.63, p = 0.008). Conclusions. Surgical radicality does not affect symptoms or QOL in vulvar cancer patients, whereas insurance, recurrence, and time since diagnosis do. This data can improve counseling and awareness of patient characteristics that would benefit from social services referral. (C) 2020 Elsevier Inc. All rights reserved.

引用

页码：252 / 259

页数：8

共 24 条

[11] The use of patient-reported outcome tools in Gynecologic Oncology research, clinical practice, and value-based care [J].