Dihydromyricetin improves social isolation-induced cognitive impairments and astrocytic changes in mice

被引：13

作者：

Watanabe, Saki ^{[1
]}

Al Omran, Alzahra ^{[1
]}

Shao, Amy S. ^{[2
]}

Xue, Chen ^{[1
]}

Zhang, Zeyu ^{[3
]}

Zhang, Jifeng ^{[1
]}

Davies, Daryl L. ^{[1
]}

Shao, Xuesi M. ^{[4
]}

Watanabe, Junji ^{[3
]}

Liang, Jing ^{[1
]}

机构：

[1] Univ Southern Calif, Sch Pharm, Titus Family Dept Clin Pharm, 1985 Zonal Ave,PSC 504, Los Angeles, CA 90033 USA

[2] Western Michigan Univ, Homer Stryker MD Sch Med, Kalamazoo, MI 49007 USA

[3] Univ Southern Calif, Sch Pharm, Translat Res Lab, Los Angeles, CA 90033 USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA

来源：

SCIENTIFIC REPORTS | 2022年 / 12卷 / 01期

关键词：

ALZHEIMERS-DISEASE; SYNAPSE LOSS; NEUROINFLAMMATION; NEUROPATHOLOGY; HIPPOCAMPUS; PREVENTS; DEFICITS; ANXIETY;

D O I：

10.1038/s41598-022-09814-5

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Social isolation induces stress, anxiety, and mild cognitive impairment that could progress towards irreversible brain damage. A probable player in the mechanism of social isolation-induced anxiety is astrocytes, specialized glial cells that support proper brain function. Using a social isolation mouse model, we observed worsened cognitive and memory abilities with reductions of Object Recognition Index (ORI) in novel object recognition test and Recognition Index (RI) in novel context recognition test. Social isolation also increased astrocyte density, reduced astrocyte size with shorter branches, and reduced morphological complexity in the hippocampus. Dihydromyricetin, a flavonoid that we previously demonstrated to have anxiolytic properties, improved memory/cognition and restored astrocyte plasticity in these mice. Our study indicates astrocytic involvement in social isolation-induced cognitive impairment as well as anxiety and suggest dihydromyricetin as an early-stage intervention against anxiety, cognitive impairment, and potential permanent brain damage.

引用

页数：9

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