Substance Use Disorders in Schizophrenia - Clinical Implications of Comorbidity

被引:169
作者
Volkow, Nora D. [1 ]
机构
[1] NIDA, Off Director, NIH, Bethesda, MD 20892 USA
关键词
schizophrenia; substance use disorders; comorbidity; NICOTINE DEPENDENCE; ABUSE; DIAGNOSIS; SMOKING; ASSOCIATION; ADDICTION; PSYCHOSIS; ALCOHOL; ILLNESS; PEOPLE;
D O I
10.1093/schbul/sbp016
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Nearly half of the people suffering from schizophrenia also present with a lifetime history of substance use disorders (SUD), a rate that is much higher than the one seen among unaffected individuals. This phenomenon suggests that the factors influencing SUD risk in schizophrenia may be more numerous and/or complex than those modulating SUD risk in the general population. It is critically important to address this comorbidity because SUD in schizophrenic patients is associated with poorer clinical outcomes and contributes significantly to their morbidity and mortality.
引用
收藏
页码:469 / 472
页数:4
相关论文
共 29 条
[1]  
[Anonymous], 2007, RES 2007 NAT SURV DR
[2]   Substance use in a population-based clinic sample of people with first-episode psychosis [J].
Barnett, Jennifer H. ;
Werners, Ursula ;
Secher, Sandra M. ;
Hill, Katherine E. ;
Brazil, Rossa ;
Masson, Kim ;
Pernet, David E. ;
Kirkbride, James B. ;
Murray, Graham K. ;
Bullmore, Edward T. ;
Jones, Peter B. .
BRITISH JOURNAL OF PSYCHIATRY, 2007, 190 :515-520
[3]   A neurobiological basis for substance abuse comorbidity in schizophrenia [J].
Chambers, RA ;
Krystal, JH ;
Self, DW .
BIOLOGICAL PSYCHIATRY, 2001, 50 (02) :71-83
[4]   The associations between substance use disorders, schizophrenia-spectrum disorders, and Axis IV psychosocial problems [J].
Compton, MT ;
Weiss, PS ;
West, JC ;
Kaslow, NJ .
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY, 2005, 40 (12) :939-946
[5]   Initiation of daily smoking and nicotine dependence in schizophrenia and mood disorders [J].
de Leon, J ;
Diaz, FJ ;
Rogers, T ;
Browne, D ;
Dinsmore, L .
SCHIZOPHRENIA RESEARCH, 2002, 56 (1-2) :47-54
[6]   A meta-analysis of worldwide studies demonstrates an association between schizophrenia and tobacco smoking behaviors [J].
de Leon, J ;
Diaz, FJ .
SCHIZOPHRENIA RESEARCH, 2005, 76 (2-3) :135-157
[7]   Smoking and schizophrenia: Epidemiological and clinical features [J].
Dervaux, A. ;
Laqueille, X. .
ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE, 2008, 34 (03) :299-305
[8]   Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophrenia [J].
Eggan, Stephen M. ;
Hashimoto, Takanori ;
Lewis, David A. .
ARCHIVES OF GENERAL PSYCHIATRY, 2008, 65 (07) :772-784
[9]   Patterns of current and lifetime substance use in schizophrenia [J].
Fowler, IL ;
Carr, VJ ;
Carter, NT ;
Lewin, TJ .
SCHIZOPHRENIA BULLETIN, 1998, 24 (03) :443-455
[10]   Behavioral interventions for dual-diagnosis patients [J].
Goldsmith, RJ ;
Garlapati, V .
PSYCHIATRIC CLINICS OF NORTH AMERICA, 2004, 27 (04) :709-+